ADRBK2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ADRBK2	BARK2, GRK3,GRK3, BARK2	adrenergic, beta, receptor kinase 2	NM_005160	pdf			NONE

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Description

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85\% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95\% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. Gene contains a YES1 pseudogene that carries many wrongly assigned reads. The gene is upregulated in human MARV 23h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	221	200	184	204	265	278	196	233	182
Read_Max	R. aegyptiacus	Transcriptome	6	5	5	7	11	7	5	7	11
Read_Max	R. aegyptiacus	Genome	8	8	9	11	6	5	6	9	12
DESeq	H. sapiens	Genome	1343.56	1280.94	1335.36	1218.11	1248.07	1151.12	1165.05	1175.25	2631.29
DESeq	R. aegyptiacus	Transcriptome	18.64	16.43	29.1	29.39	32.76	26.66	19.91	24.13	39.49
DESeq	R. aegyptiacus	Genome	58.44	67.54	81.45	67.15	59.16	66.58	67.47	68.99	88.19

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1343.56	1218.11	1165.05	-0.14	-0.21	-0.06
7h	1280.94	1248.07	1175.25	-0.04	-0.12	-0.09
23h	1335.36	1151.12	2631.29	-0.21	0.98	1.19

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1343.56	1280.94	1335.36	-0.07	-0.01	0.06
Ebov	1218.11	1248.07	1151.12	0.04	-0.08	-0.12
Marv	1165.05	1175.25	2631.29	0.01	1.18	1.16

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	18.64	29.39	19.91	0.66	0.1	-0.56
7h	16.43	32.76	24.13	1.0	0.55	-0.44
23h	29.1	26.66	39.49	-0.13	0.44	0.57

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	18.64	16.43	29.1	-0.18	0.64	0.82
Ebov	29.39	32.76	26.66	0.16	-0.14	-0.3
Marv	19.91	24.13	39.49	0.28	0.99	0.71

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material