GRK4

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GRK4 GPRK2L, GPRK4, ITI1,GPRK4 G protein-coupled receptor kinase 4 NM_005307 pdf

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Description

Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 1, mRNA. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome13 11 11 8 9 11 12 16 23
Read_Max
batR. aegyptiacusTranscriptome 28 24 29 20 17 31 20 41 29
Read_Max
bat_genomeR. aegyptiacusGenome 74 65 54 58 44 33 42 88 82
DESeq
humanH. sapiensGenome 186.71 157.04 131.06 135.6 149.77 114.17 186.97 157.67 253.26
DESeq
batR. aegyptiacusTranscriptome 162.31 148.05 172.02 161.24 119.27 197.33 174.54 194.33 195.19
DESeq
bat_genomeR. aegyptiacusGenome 1095.72 1214.78 1319.97 898.61 1078.19 1097.85 1068.31 1269.51 1359.63

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 186.71 135.6 186.97 -0.46 0.0 0.46
7h 157.04 149.77 157.67 -0.07 0.01 0.07
23h 131.06 114.17 253.26 -0.2 0.95 1.15

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 186.71 157.04 131.06 -0.25 -0.51 -0.26
Ebov 135.6 149.77 114.17 0.14 -0.25 -0.39
Marv 186.97 157.67 253.26 -0.25 0.44 0.68

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 162.31 161.24 174.54 -0.01 0.1 0.11
7h 148.05 119.27 194.33 -0.31 0.39 0.7
23h 172.02 197.33 195.19 0.2 0.18 -0.02

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 162.31 148.05 172.02 -0.13 0.08 0.22
Ebov 161.24 119.27 197.33 -0.43 0.29 0.73
Marv 174.54 194.33 195.19 0.15 0.16 0.01