GRK4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
GRK4	GPRK2L, GPRK4, ITI1,GPRK4	G protein-coupled receptor kinase 4	NM_005307	pdf

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Description

Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 1, mRNA. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	13	11	11	8	9	11	12	16	23
Read_Max	R. aegyptiacus	Transcriptome	28	24	29	20	17	31	20	41	29
Read_Max	R. aegyptiacus	Genome	74	65	54	58	44	33	42	88	82
DESeq	H. sapiens	Genome	186.71	157.04	131.06	135.6	149.77	114.17	186.97	157.67	253.26
DESeq	R. aegyptiacus	Transcriptome	162.31	148.05	172.02	161.24	119.27	197.33	174.54	194.33	195.19
DESeq	R. aegyptiacus	Genome	1095.72	1214.78	1319.97	898.61	1078.19	1097.85	1068.31	1269.51	1359.63

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	186.71	135.6	186.97	-0.46	0.0	0.46
7h	157.04	149.77	157.67	-0.07	0.01	0.07
23h	131.06	114.17	253.26	-0.2	0.95	1.15

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	186.71	157.04	131.06	-0.25	-0.51	-0.26
Ebov	135.6	149.77	114.17	0.14	-0.25	-0.39
Marv	186.97	157.67	253.26	-0.25	0.44	0.68

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	162.31	161.24	174.54	-0.01	0.1	0.11
7h	148.05	119.27	194.33	-0.31	0.39	0.7
23h	172.02	197.33	195.19	0.2	0.18	-0.02

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	162.31	148.05	172.02	-0.13	0.08	0.22
Ebov	161.24	119.27	197.33	-0.43	0.29	0.73
Marv	174.54	194.33	195.19	0.15	0.16	0.01

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material