DNM1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DNM1 DNM dynamin 1 NM_004408 pdf

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Description

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. The gene is lowly but stably expressed in human, and shows comparibly large intron retention at a central intron. The bat homologs are almost not expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome16 16 22 18 14 19 12 23 19
Read_Max
batR. aegyptiacusTranscriptome 214 208 132 221 174 211 150 228 276
Read_Max
bat_genomeR. aegyptiacusGenome 3 3 9 3 5 5 4 4 5
DESeq
humanH. sapiensGenome 435.33 412.01 707.89 338.64 352.19 214.18 302.76 494.2 712.12
DESeq
batR. aegyptiacusTranscriptome 2673.49 2593.36 2188.77 2549.3 2612.79 2958.73 2439.39 2708.49 2940.9
DESeq
bat_genomeR. aegyptiacusGenome 14.61 23.73 60.25 27.65 23.44 48.3 16.87 20.62 42.81

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 435.33 338.64 302.76 -0.36 -0.52 -0.16
7h 412.01 352.19 494.2 -0.23 0.26 0.49
23h 707.89 214.18 712.12 -1.72 0.01 1.73

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 435.33 412.01 707.89 -0.08 0.7 0.78
Ebov 338.64 352.19 214.18 0.06 -0.66 -0.72
Marv 302.76 494.2 712.12 0.71 1.23 0.53

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2673.49 2549.3 2439.39 -0.07 -0.13 -0.06
7h 2593.36 2612.79 2708.49 0.01 0.06 0.05
23h 2188.77 2958.73 2940.9 0.43 0.43 -0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2673.49 2593.36 2188.77 -0.04 -0.29 -0.24
Ebov 2549.3 2612.79 2958.73 0.04 0.21 0.18
Marv 2439.39 2708.49 2940.9 0.15 0.27 0.12