ARF3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ARF3 ADP-ribosylation factor 3 NM_001659 pdf

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Description

ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. Gene is highly expressed and downregulated in human wt 7h, but otherwise uniformely. The bat homolog is uniformely expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome732 579 567 516 592 513 706 663 512
Read_Max
batR. aegyptiacusTranscriptome 848 646 644 598 503 637 602 625 860
Read_Max
bat_genomeR. aegyptiacusGenome 962 587 548 634 429 371 508 745 957
DESeq
humanH. sapiensGenome 10881.54 7264.53 7380.67 8006.31 7049.28 6337.17 8166.9 7159.18 7845.12
DESeq
batR. aegyptiacusTranscriptome 2988.54 2875.65 3625.3 2551.14 2531.75 2965.15 3160.23 2577.94 3103.59
DESeq
bat_genomeR. aegyptiacusGenome 4182.65 3307.57 4583.61 4413.06 3535.91 3869.24 4374.43 3343.06 4083.18

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10881.54 8006.31 8166.9 -0.44 -0.41 0.03
7h 7264.53 7049.28 7159.18 -0.04 -0.02 0.02
23h 7380.67 6337.17 7845.12 -0.22 0.09 0.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10881.54 7264.53 7380.67 -0.58 -0.56 0.02
Ebov 8006.31 7049.28 6337.17 -0.18 -0.34 -0.15
Marv 8166.9 7159.18 7845.12 -0.19 -0.06 0.13

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2988.54 2551.14 3160.23 -0.23 0.08 0.31
7h 2875.65 2531.75 2577.94 -0.18 -0.16 0.03
23h 3625.3 2965.15 3103.59 -0.29 -0.22 0.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2988.54 2875.65 3625.3 -0.06 0.28 0.33
Ebov 2551.14 2531.75 2965.15 -0.01 0.22 0.23
Marv 3160.23 2577.94 3103.59 -0.29 -0.03 0.27