DIAPH1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DIAPH1	DFNA1, hDIA1, LFHL1,hDIA1	diaphanous-related formin 1	NM_005219	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The DIAPH1 is known to be associated in the CDC42 pathway and is up-regulated in human cells infected with ebola and Marburg-virus. Also the same expression pattern is observed in the surrounding genes HDAC3 (upstream) and PCDHGA1 (downstream).

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	510	571	520	510	712	655	630	809	467
Read_Max	R. aegyptiacus	Transcriptome	169	133	111	132	108	120	97	191	135
Read_Max	R. aegyptiacus	Genome	172	141	96	137	94	78	94	223	161
DESeq	H. sapiens	Genome	12380.38	12303.73	11529.68	12607.83	12259.48	13252.34	12140.64	12681.1	11420.32
DESeq	R. aegyptiacus	Transcriptome	1709.85	1663.89	1409.43	1400.14	1437.76	1547.23	1377.05	1560.06	1317.44
DESeq	R. aegyptiacus	Genome	3274.28	2759.96	2758.2	3622.09	3006.86	3471.09	3165.56	2997.34	2875.09

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	12380.38	12607.83	12140.64	0.03	-0.03	-0.05
7h	12303.73	12259.48	12681.1	-0.01	0.04	0.05
23h	11529.68	13252.34	11420.32	0.2	-0.01	-0.21

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	12380.38	12303.73	11529.68	-0.01	-0.1	-0.09
Ebov	12607.83	12259.48	13252.34	-0.04	0.07	0.11
Marv	12140.64	12681.1	11420.32	0.06	-0.09	-0.15

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1709.85	1400.14	1377.05	-0.29	-0.31	-0.02
7h	1663.89	1437.76	1560.06	-0.21	-0.09	0.12
23h	1409.43	1547.23	1317.44	0.13	-0.1	-0.23

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1709.85	1663.89	1409.43	-0.04	-0.28	-0.24
Ebov	1400.14	1437.76	1547.23	0.04	0.14	0.11
Marv	1377.05	1560.06	1317.44	0.18	-0.06	-0.24

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material