DIAPH1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DIAPH1 DFNA1, hDIA1, LFHL1,hDIA1 diaphanous-related formin 1 NM_005219 pdf

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Description

This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The DIAPH1 is known to be associated in the CDC42 pathway and is up-regulated in human cells infected with ebola and Marburg-virus. Also the same expression pattern is observed in the surrounding genes HDAC3 (upstream) and PCDHGA1 (downstream).

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome510 571 520 510 712 655 630 809 467
Read_Max
batR. aegyptiacusTranscriptome 169 133 111 132 108 120 97 191 135
Read_Max
bat_genomeR. aegyptiacusGenome 172 141 96 137 94 78 94 223 161
DESeq
humanH. sapiensGenome 12380.38 12303.73 11529.68 12607.83 12259.48 13252.34 12140.64 12681.1 11420.32
DESeq
batR. aegyptiacusTranscriptome 1709.85 1663.89 1409.43 1400.14 1437.76 1547.23 1377.05 1560.06 1317.44
DESeq
bat_genomeR. aegyptiacusGenome 3274.28 2759.96 2758.2 3622.09 3006.86 3471.09 3165.56 2997.34 2875.09

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 12380.38 12607.83 12140.64 0.03 -0.03 -0.05
7h 12303.73 12259.48 12681.1 -0.01 0.04 0.05
23h 11529.68 13252.34 11420.32 0.2 -0.01 -0.21

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 12380.38 12303.73 11529.68 -0.01 -0.1 -0.09
Ebov 12607.83 12259.48 13252.34 -0.04 0.07 0.11
Marv 12140.64 12681.1 11420.32 0.06 -0.09 -0.15

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1709.85 1400.14 1377.05 -0.29 -0.31 -0.02
7h 1663.89 1437.76 1560.06 -0.21 -0.09 0.12
23h 1409.43 1547.23 1317.44 0.13 -0.1 -0.23

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1709.85 1663.89 1409.43 -0.04 -0.28 -0.24
Ebov 1400.14 1437.76 1547.23 0.04 0.14 0.11
Marv 1377.05 1560.06 1317.44 0.18 -0.06 -0.24