LPIN1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
LPIN1 PAP1,KIAA0188 lipin 1 NM_145693 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens lipin 1 (LPIN1), transcript variant 4, mRNA. This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012].

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome63 92 99 66 138 97 104 123 100
Read_Max
batR. aegyptiacusTranscriptome 31 33 51 46 45 50 28 50 60
Read_Max
bat_genomeR. aegyptiacusGenome 37 53 49 28 39 30 22 74 81
DESeq
humanH. sapiensGenome 1573.92 2144.77 2262.65 1835.22 2247.18 1726.17 1735.23 2124.87 2672.61
DESeq
batR. aegyptiacusTranscriptome 329.49 363.17 810.88 609.0 618.63 754.23 313.59 618.18 762.0
DESeq
bat_genomeR. aegyptiacusGenome 670.32 1215.7 1568.78 648.78 1212.12 1415.06 611.75 1188.63 1600.22

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1573.92 1835.22 1735.23 0.22 0.14 -0.08
7h 2144.77 2247.18 2124.87 0.07 -0.01 -0.08
23h 2262.65 1726.17 2672.61 -0.39 0.24 0.63

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1573.92 2144.77 2262.65 0.45 0.52 0.08
Ebov 1835.22 2247.18 1726.17 0.29 -0.09 -0.38
Marv 1735.23 2124.87 2672.61 0.29 0.62 0.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 329.49 609.0 313.59 0.89 -0.07 -0.96
7h 363.17 618.63 618.18 0.77 0.77 -0.0
23h 810.88 754.23 762.0 -0.1 -0.09 0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 329.49 363.17 810.88 0.14 1.3 1.16
Ebov 609.0 618.63 754.23 0.02 0.31 0.29
Marv 313.59 618.18 762.0 0.98 1.28 0.3