LDLR

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
LDLR	FH, FHC, LDLCQ2,LDLCQ2	low density lipoprotein receptor		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Gene is highly upregulated in human 23h EBOV and MARV. Homolog in bat is uniformely highly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	177	220	329	181	256	960	281	320	512
Read_Max	R. aegyptiacus	Transcriptome	366	359	431	417	404	437	260	514	722
Read_Max	R. aegyptiacus	Genome	591	617	497	461	452	315	264	793	1141
DESeq	H. sapiens	Genome	4650.75	5289.04	5136.88	5412.4	4590.11	16860.6	5377.39	6100.84	6302.18
DESeq	R. aegyptiacus	Transcriptome	3798.43	4023.88	5806.96	4837.56	4422.97	4720.54	3392.73	4289.85	7054.65
DESeq	R. aegyptiacus	Genome	8701.32	10599.92	12650.69	9302.1	9968.19	10721.33	7762.64	9764.34	15685.43

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4650.75	5412.4	5377.39	0.22	0.21	-0.01
7h	5289.04	4590.11	6100.84	-0.2	0.21	0.41
23h	5136.88	16860.6	6302.18	1.71	0.29	-1.42

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4650.75	5289.04	5136.88	0.19	0.14	-0.04
Ebov	5412.4	4590.11	16860.6	-0.24	1.64	1.88
Marv	5377.39	6100.84	6302.18	0.18	0.23	0.05

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3798.43	4837.56	3392.73	0.35	-0.16	-0.51
7h	4023.88	4422.97	4289.85	0.14	0.09	-0.04
23h	5806.96	4720.54	7054.65	-0.3	0.28	0.58

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3798.43	4023.88	5806.96	0.08	0.61	0.53
Ebov	4837.56	4422.97	4720.54	-0.13	-0.04	0.09
Marv	3392.73	4289.85	7054.65	0.34	1.06	0.72

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material