NCK2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NCK2 GRB4, SH2/SH3 Adaptor Protein NCK-Beta,NCKbeta NCK adaptor protein 2 NM_003581 pdf

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Description

Homo sapiens NCK adaptor protein 2 (NCK2), transcript variant 1, mRNA. This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome42 52 44 37 53 94 57 72 52
Read_Max
batR. aegyptiacusTranscriptome 166 207 150 168 169 216 150 158 273
Read_Max
bat_genomeR. aegyptiacusGenome 176 182 134 181 139 126 130 201 304
DESeq
humanH. sapiensGenome 472.88 484.42 467.63 461.84 467.63 678.7 445.74 491.8 576.21
DESeq
batR. aegyptiacusTranscriptome 973.04 999.46 936.7 846.16 1029.29 1258.52 896.49 864.39 1373.42
DESeq
bat_genomeR. aegyptiacusGenome 1838.24 1732.28 1863.35 1971.02 1985.6 2378.46 1954.44 1664.39 2577.99

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 472.88 461.84 445.74 -0.03 -0.09 -0.05
7h 484.42 467.63 491.8 -0.05 0.02 0.07
23h 467.63 678.7 576.21 0.54 0.3 -0.24

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 472.88 484.42 467.63 0.03 -0.02 -0.05
Ebov 461.84 467.63 678.7 0.02 0.56 0.54
Marv 445.74 491.8 576.21 0.14 0.37 0.23

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 973.04 846.16 896.49 -0.2 -0.12 0.08
7h 999.46 1029.29 864.39 0.04 -0.21 -0.25
23h 936.7 1258.52 1373.42 0.43 0.55 0.13

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 973.04 999.46 936.7 0.04 -0.05 -0.09
Ebov 846.16 1029.29 1258.52 0.28 0.57 0.29
Marv 896.49 864.39 1373.42 -0.05 0.62 0.67