NPHP1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NPHP1	JBTS4, NPH1, SLSN1	nephronophthisis 1 (juvenile)	NM_000272	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The nephronophthisis 1 (juvenile) together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). (Source: Uniprot)

Slightly upregulated in bat during the first 3 hours of Marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	12	5	20	10	26	15	6	17	24
Read_Max	R. aegyptiacus	Transcriptome	34	30	50	49	35	42	31	58	53
Read_Max	R. aegyptiacus	Genome	78	85	68	42	52	41	47	126	112
DESeq	H. sapiens	Genome	26.37	33.64	34.76	34.08	21.32	11.53	25.56	22.58	34.71
DESeq	R. aegyptiacus	Transcriptome	118.62	138.97	235.54	192.37	184.98	193.48	138.94	245.56	168.07
DESeq	R. aegyptiacus	Genome	575.79	787.65	863.61	516.45	774.6	648.79	553.27	964.22	768.0

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	26.37	34.08	25.56	0.37	-0.05	-0.42
7h	33.64	21.32	22.58	-0.66	-0.58	0.08
23h	34.76	11.53	34.71	-1.59	-0.0	1.59

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	26.37	33.64	34.76	0.35	0.4	0.05
Ebov	34.08	21.32	11.53	-0.68	-1.56	-0.89
Marv	25.56	22.58	34.71	-0.18	0.44	0.62

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	118.62	192.37	138.94	0.7	0.23	-0.47
7h	138.97	184.98	245.56	0.41	0.82	0.41
23h	235.54	193.48	168.07	-0.28	-0.49	-0.2

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	118.62	138.97	235.54	0.23	0.99	0.76
Ebov	192.37	184.98	193.48	-0.06	0.01	0.06
Marv	138.94	245.56	168.07	0.82	0.27	-0.55

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material