NPHP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NPHP1 JBTS4, NPH1, SLSN1 nephronophthisis 1 (juvenile) NM_000272 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The nephronophthisis 1 (juvenile) together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). (Source: Uniprot)

Slightly upregulated in bat during the first 3 hours of Marburg virus infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome12 5 20 10 26 15 6 17 24
Read_Max
batR. aegyptiacusTranscriptome 34 30 50 49 35 42 31 58 53
Read_Max
bat_genomeR. aegyptiacusGenome 78 85 68 42 52 41 47 126 112
DESeq
humanH. sapiensGenome 26.37 33.64 34.76 34.08 21.32 11.53 25.56 22.58 34.71
DESeq
batR. aegyptiacusTranscriptome 118.62 138.97 235.54 192.37 184.98 193.48 138.94 245.56 168.07
DESeq
bat_genomeR. aegyptiacusGenome 575.79 787.65 863.61 516.45 774.6 648.79 553.27 964.22 768.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 26.37 34.08 25.56 0.37 -0.05 -0.42
7h 33.64 21.32 22.58 -0.66 -0.58 0.08
23h 34.76 11.53 34.71 -1.59 -0.0 1.59

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 26.37 33.64 34.76 0.35 0.4 0.05
Ebov 34.08 21.32 11.53 -0.68 -1.56 -0.89
Marv 25.56 22.58 34.71 -0.18 0.44 0.62

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 118.62 192.37 138.94 0.7 0.23 -0.47
7h 138.97 184.98 245.56 0.41 0.82 0.41
23h 235.54 193.48 168.07 -0.28 -0.49 -0.2

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 118.62 138.97 235.54 0.23 0.99 0.76
Ebov 192.37 184.98 193.48 -0.06 0.01 0.06
Marv 138.94 245.56 168.07 0.82 0.27 -0.55