CAV1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CAV1 BSCL3, CGL3, PPH3 caveolin 1, caveolae protein, 22kDa NM_001753 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens caveolin 1, caveolae protein, 22kDa (CAV1). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. [provided by RefSeq, Mar 2010].

This gene is weakly expressed in human cells with a minor increase in 23h-MARV and 23h-EB. In bat cells, this gene is extremely well expressed, with a clear trend (3 h$>$7 h$>$23 h) for all samples.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome31 35 23 23 23 37 34 26 75
Read_Max
batR. aegyptiacusTranscriptome 2371 2304 762 1333 1232 941 1445 1654 1107
Read_Max
bat_genomeR. aegyptiacusGenome 2883 1536 649 2468 1130 579 1258 2139 1284
DESeq
humanH. sapiensGenome 311.52 249.85 172.76 254.23 189.6 285.24 284.34 182.45 764.32
DESeq
batR. aegyptiacusTranscriptome 7642.92 7773.55 3795.09 6012.36 5872.87 4060.99 7605.41 5839.82 4089.39
DESeq
bat_genomeR. aegyptiacusGenome 18217.35 15021.88 8768.9 18226.97 15939.51 10469.39 19960.44 15092.93 10873.63

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 311.52 254.23 284.34 -0.29 -0.13 0.16
7h 249.85 189.6 182.45 -0.4 -0.45 -0.06
23h 172.76 285.24 764.32 0.72 2.15 1.42

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 311.52 249.85 172.76 -0.32 -0.85 -0.53
Ebov 254.23 189.6 285.24 -0.42 0.17 0.59
Marv 284.34 182.45 764.32 -0.64 1.43 2.07

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7642.92 6012.36 7605.41 -0.35 -0.01 0.34
7h 7773.55 5872.87 5839.82 -0.4 -0.41 -0.01
23h 3795.09 4060.99 4089.39 0.1 0.11 0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7642.92 7773.55 3795.09 0.02 -1.01 -1.03
Ebov 6012.36 5872.87 4060.99 -0.03 -0.57 -0.53
Marv 7605.41 5839.82 4089.39 -0.38 -0.9 -0.51