CAV1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CAV1	BSCL3, CGL3, PPH3	caveolin 1, caveolae protein, 22kDa	NM_001753	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens caveolin 1, caveolae protein, 22kDa (CAV1). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. [provided by RefSeq, Mar 2010].

This gene is weakly expressed in human cells with a minor increase in 23h-MARV and 23h-EB. In bat cells, this gene is extremely well expressed, with a clear trend (3 h$>$7 h$>$23 h) for all samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	31	35	23	23	23	37	34	26	75
Read_Max	R. aegyptiacus	Transcriptome	2371	2304	762	1333	1232	941	1445	1654	1107
Read_Max	R. aegyptiacus	Genome	2883	1536	649	2468	1130	579	1258	2139	1284
DESeq	H. sapiens	Genome	311.52	249.85	172.76	254.23	189.6	285.24	284.34	182.45	764.32
DESeq	R. aegyptiacus	Transcriptome	7642.92	7773.55	3795.09	6012.36	5872.87	4060.99	7605.41	5839.82	4089.39
DESeq	R. aegyptiacus	Genome	18217.35	15021.88	8768.9	18226.97	15939.51	10469.39	19960.44	15092.93	10873.63

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	311.52	254.23	284.34	-0.29	-0.13	0.16
7h	249.85	189.6	182.45	-0.4	-0.45	-0.06
23h	172.76	285.24	764.32	0.72	2.15	1.42

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	311.52	249.85	172.76	-0.32	-0.85	-0.53
Ebov	254.23	189.6	285.24	-0.42	0.17	0.59
Marv	284.34	182.45	764.32	-0.64	1.43	2.07

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7642.92	6012.36	7605.41	-0.35	-0.01	0.34
7h	7773.55	5872.87	5839.82	-0.4	-0.41	-0.01
23h	3795.09	4060.99	4089.39	0.1	0.11	0.01

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7642.92	7773.55	3795.09	0.02	-1.01	-1.03
Ebov	6012.36	5872.87	4060.99	-0.03	-0.57	-0.53
Marv	7605.41	5839.82	4089.39	-0.38	-0.9	-0.51

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material