RAB5B

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
RAB5B RAB5B, member RAS oncogene family pdf

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Description

Ras-related protein Rab-5B (RAB5B) is involved in protein transport. Probably also in vesicular traffic. It shows a 2-fold upregulation in EBOV infected human cells after 7h and again a upregulation after 23h. For MARV the same pattern can be observed, but with lower changes. Between first and second exon (chr12:56374250-56375000) mapped reads in all samples could be observed. This seems to be an already known pseudogen.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome241 367 378 225 529 317 344 475 419
Read_Max
batR. aegyptiacusTranscriptome 240 202 231 226 226 230 185 319 313
Read_Max
bat_genomeR. aegyptiacusGenome 502 430 439 321 362 300 373 798 786
DESeq
humanH. sapiensGenome 4616.25 6321.15 6061.2 4886.55 6392.42 4965.97 4790.54 5907.4 6702.32
DESeq
batR. aegyptiacusTranscriptome 1167.11 1059.37 1571.9 1214.26 1301.97 1306.0 1149.0 1360.11 1303.44
DESeq
bat_genomeR. aegyptiacusGenome 5618.69 6255.54 7693.29 5305.75 6752.61 6848.18 6728.08 6947.79 6888.92

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4616.25 4886.55 4790.54 0.08 0.05 -0.03
7h 6321.15 6392.42 5907.4 0.02 -0.1 -0.11
23h 6061.2 4965.97 6702.32 -0.29 0.15 0.43

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4616.25 6321.15 6061.2 0.45 0.39 -0.06
Ebov 4886.55 6392.42 4965.97 0.39 0.02 -0.36
Marv 4790.54 5907.4 6702.32 0.3 0.48 0.18

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1167.11 1214.26 1149.0 0.06 -0.02 -0.08
7h 1059.37 1301.97 1360.11 0.3 0.36 0.06
23h 1571.9 1306.0 1303.44 -0.27 -0.27 -0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1167.11 1059.37 1571.9 -0.14 0.43 0.57
Ebov 1214.26 1301.97 1306.0 0.1 0.11 0.0
Marv 1149.0 1360.11 1303.44 0.24 0.18 -0.06