KIF7

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
KIF7 ACLS, HLS2, JBTS12, UNQ340,JBTS12 kinesin family member 7 NM_198525 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Kinesin family member 7: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity) (Source: Uniprot).

It seems slightly upregulated during the first 3 hours of Ebola infection in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome106 144 151 63 219 247 85 90 87
Read_Max
batR. aegyptiacusTranscriptome 34 32 32 27 32 35 29 30 36
Read_Max
bat_genomeR. aegyptiacusGenome 36 36 32 31 30 25 29 42 48
DESeq
humanH. sapiensGenome 640.32 908.69 710.87 866.78 935.08 1407.72 888.73 1006.58 628.4
DESeq
batR. aegyptiacusTranscriptome 359.74 376.78 531.15 424.95 433.56 492.46 430.39 406.67 489.09
DESeq
bat_genomeR. aegyptiacusGenome 596.42 647.09 773.23 659.64 670.8 736.25 624.12 610.57 668.69

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 640.32 866.78 888.73 0.44 0.47 0.04
7h 908.69 935.08 1006.58 0.04 0.15 0.11
23h 710.87 1407.72 628.4 0.99 -0.18 -1.16

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 640.32 908.69 710.87 0.5 0.15 -0.35
Ebov 866.78 935.08 1407.72 0.11 0.7 0.59
Marv 888.73 1006.58 628.4 0.18 -0.5 -0.68

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 359.74 424.95 430.39 0.24 0.26 0.02
7h 376.78 433.56 406.67 0.2 0.11 -0.09
23h 531.15 492.46 489.09 -0.11 -0.12 -0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 359.74 376.78 531.15 0.07 0.56 0.5
Ebov 424.95 433.56 492.46 0.03 0.21 0.18
Marv 430.39 406.67 489.09 -0.08 0.18 0.27