ARFGEF1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ARFGEF1	DKFZP434L057, BIG1, ARFGEP1, p200	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	NM_006421	pdf		NONE

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Description

The gene ARFGEF1 is weakly expressed in all human and bat datasets without significant changes in expression levels. ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. (provided by RefSeq, Aug 2011)

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	145	174	143	165	224	224	192	198	168
Read_Max	R. aegyptiacus	Transcriptome	369	322	303	359	316	391	253	344	306
Read_Max	R. aegyptiacus	Genome	392	337	244	301	228	213	199	406	322
DESeq	H. sapiens	Genome	3351.83	3929.55	3750.9	3676.28	3975.52	5446.29	3580.87	3331.89	4836.43
DESeq	R. aegyptiacus	Transcriptome	6270.97	5790.25	6586.3	6934.44	6443.41	7598.72	5306.06	6352.06	5457.43
DESeq	R. aegyptiacus	Genome	6596.68	6915.41	6507.22	6403.83	6470.23	7929.06	5621.54	6229.38	5552.4

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3351.83	3676.28	3580.87	0.13	0.1	-0.04
7h	3929.55	3975.52	3331.89	0.02	-0.24	-0.25
23h	3750.9	5446.29	4836.43	0.54	0.37	-0.17

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3351.83	3929.55	3750.9	0.23	0.16	-0.07
Ebov	3676.28	3975.52	5446.29	0.11	0.57	0.45
Marv	3580.87	3331.89	4836.43	-0.1	0.43	0.54

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6270.97	6934.44	5306.06	0.15	-0.24	-0.39
7h	5790.25	6443.41	6352.06	0.15	0.13	-0.02
23h	6586.3	7598.72	5457.43	0.21	-0.27	-0.48

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6270.97	5790.25	6586.3	-0.12	0.07	0.19
Ebov	6934.44	6443.41	7598.72	-0.11	0.13	0.24
Marv	5306.06	6352.06	5457.43	0.26	0.04	-0.22

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material