ARFGEF1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ARFGEF1 DKFZP434L057, BIG1, ARFGEP1, p200 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) NM_006421 pdf NONE

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Description

The gene ARFGEF1 is weakly expressed in all human and bat datasets without significant changes in expression levels. ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. (provided by RefSeq, Aug 2011)

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome145 174 143 165 224 224 192 198 168
Read_Max
batR. aegyptiacusTranscriptome 369 322 303 359 316 391 253 344 306
Read_Max
bat_genomeR. aegyptiacusGenome 392 337 244 301 228 213 199 406 322
DESeq
humanH. sapiensGenome 3351.83 3929.55 3750.9 3676.28 3975.52 5446.29 3580.87 3331.89 4836.43
DESeq
batR. aegyptiacusTranscriptome 6270.97 5790.25 6586.3 6934.44 6443.41 7598.72 5306.06 6352.06 5457.43
DESeq
bat_genomeR. aegyptiacusGenome 6596.68 6915.41 6507.22 6403.83 6470.23 7929.06 5621.54 6229.38 5552.4

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3351.83 3676.28 3580.87 0.13 0.1 -0.04
7h 3929.55 3975.52 3331.89 0.02 -0.24 -0.25
23h 3750.9 5446.29 4836.43 0.54 0.37 -0.17

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3351.83 3929.55 3750.9 0.23 0.16 -0.07
Ebov 3676.28 3975.52 5446.29 0.11 0.57 0.45
Marv 3580.87 3331.89 4836.43 -0.1 0.43 0.54

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6270.97 6934.44 5306.06 0.15 -0.24 -0.39
7h 5790.25 6443.41 6352.06 0.15 0.13 -0.02
23h 6586.3 7598.72 5457.43 0.21 -0.27 -0.48

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6270.97 5790.25 6586.3 -0.12 0.07 0.19
Ebov 6934.44 6443.41 7598.72 -0.11 0.13 0.24
Marv 5306.06 6352.06 5457.43 0.26 0.04 -0.22