Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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STAT3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
STAT3	APRF, HIES, ADMIO	signal transducer and activator of transcription 3 (acute-phase response factor)	NM_139276, NM_003150	pdf

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Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 is well expressed in both human and bat. In human Ebola-infected cells are slightly up-regulated, whereas Marburg-infected cells are slightly down-regulated. In bat both Ebola- and Marburg-infected cells are sligthly up-regulated.

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