STAT3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
STAT3 APRF, HIES, ADMIO signal transducer and activator of transcription 3 (acute-phase response factor) NM_139276, NM_003150 pdf

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Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

STAT3 is well expressed in both human and bat. In human Ebola-infected cells are slightly up-regulated, whereas Marburg-infected cells are slightly down-regulated. In bat both Ebola- and Marburg-infected cells are sligthly up-regulated.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome138 166 125 120 203 203 150 183 134
Read_Max
batR. aegyptiacusTranscriptome 213 179 242 215 174 318 119 224 256
Read_Max
bat_genomeR. aegyptiacusGenome 226 229 210 171 138 167 96 267 281
DESeq
humanH. sapiensGenome 2308.63 2593.52 2512.85 2289.21 2552.85 3065.78 2168.57 2538.14 2556.27
DESeq
batR. aegyptiacusTranscriptome 1985.41 1802.76 3158.67 2189.45 2147.38 3045.99 1608.43 2101.22 2527.16
DESeq
bat_genomeR. aegyptiacusGenome 2402.0 2628.53 3529.2 2324.54 2550.37 3736.08 2037.65 2420.86 2936.74

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2308.63 2289.21 2168.57 -0.01 -0.09 -0.08
7h 2593.52 2552.85 2538.14 -0.02 -0.03 -0.01
23h 2512.85 3065.78 2556.27 0.29 0.02 -0.26

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2308.63 2593.52 2512.85 0.17 0.12 -0.05
Ebov 2289.21 2552.85 3065.78 0.16 0.42 0.26
Marv 2168.57 2538.14 2556.27 0.23 0.24 0.01

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1985.41 2189.45 1608.43 0.14 -0.3 -0.44
7h 1802.76 2147.38 2101.22 0.25 0.22 -0.03
23h 3158.67 3045.99 2527.16 -0.05 -0.32 -0.27

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1985.41 1802.76 3158.67 -0.14 0.67 0.81
Ebov 2189.45 2147.38 3045.99 -0.03 0.48 0.5
Marv 1608.43 2101.22 2527.16 0.39 0.65 0.27