VPS36

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VPS36 CGI-145, Eap45 vacuolar protein sorting 36 homolog (S. cerevisiae) pdf

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Description

Homo sapiens vacuolar protein sorting 36 homolog (S. cerevisiae) (VPS36). Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. VPS36 shows a slightly down regulation in human EBOV/MARV at 23h post infection. A similiar pattern could be observed within the bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome181 212 161 183 236 123 229 251 132
Read_Max
batR. aegyptiacusTranscriptome 349 308 259 327 270 278 256 326 378
Read_Max
bat_genomeR. aegyptiacusGenome 350 279 183 252 216 156 205 390 394
DESeq
humanH. sapiensGenome 2555.22 2525.19 2650.85 2713.54 2845.51 1155.06 2608.05 2492.58 2309.44
DESeq
batR. aegyptiacusTranscriptome 1862.75 1820.92 2142.35 2065.83 2031.3 1942.45 2072.3 2094.61 2167.65
DESeq
bat_genomeR. aegyptiacusGenome 2566.14 2895.04 2687.91 2649.42 2939.9 2796.19 3183.55 2987.03 2947.87

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2555.22 2713.54 2608.05 0.09 0.03 -0.06
7h 2525.19 2845.51 2492.58 0.17 -0.02 -0.19
23h 2650.85 1155.06 2309.44 -1.2 -0.2 1.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2555.22 2525.19 2650.85 -0.02 0.05 0.07
Ebov 2713.54 2845.51 1155.06 0.07 -1.23 -1.3
Marv 2608.05 2492.58 2309.44 -0.07 -0.18 -0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1862.75 2065.83 2072.3 0.15 0.15 0.0
7h 1820.92 2031.3 2094.61 0.16 0.2 0.04
23h 2142.35 1942.45 2167.65 -0.14 0.02 0.16

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1862.75 1820.92 2142.35 -0.03 0.2 0.23
Ebov 2065.83 2031.3 1942.45 -0.02 -0.09 -0.06
Marv 2072.3 2094.61 2167.65 0.02 0.06 0.05