VPS36

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
VPS36	CGI-145, Eap45	vacuolar protein sorting 36 homolog (S. cerevisiae)		pdf

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Description

Homo sapiens vacuolar protein sorting 36 homolog (S. cerevisiae) (VPS36). Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. VPS36 shows a slightly down regulation in human EBOV/MARV at 23h post infection. A similiar pattern could be observed within the bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	181	212	161	183	236	123	229	251	132
Read_Max	R. aegyptiacus	Transcriptome	349	308	259	327	270	278	256	326	378
Read_Max	R. aegyptiacus	Genome	350	279	183	252	216	156	205	390	394
DESeq	H. sapiens	Genome	2555.22	2525.19	2650.85	2713.54	2845.51	1155.06	2608.05	2492.58	2309.44
DESeq	R. aegyptiacus	Transcriptome	1862.75	1820.92	2142.35	2065.83	2031.3	1942.45	2072.3	2094.61	2167.65
DESeq	R. aegyptiacus	Genome	2566.14	2895.04	2687.91	2649.42	2939.9	2796.19	3183.55	2987.03	2947.87

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2555.22	2713.54	2608.05	0.09	0.03	-0.06
7h	2525.19	2845.51	2492.58	0.17	-0.02	-0.19
23h	2650.85	1155.06	2309.44	-1.2	-0.2	1.0

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2555.22	2525.19	2650.85	-0.02	0.05	0.07
Ebov	2713.54	2845.51	1155.06	0.07	-1.23	-1.3
Marv	2608.05	2492.58	2309.44	-0.07	-0.18	-0.11

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1862.75	2065.83	2072.3	0.15	0.15	0.0
7h	1820.92	2031.3	2094.61	0.16	0.2	0.04
23h	2142.35	1942.45	2167.65	-0.14	0.02	0.16

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1862.75	1820.92	2142.35	-0.03	0.2	0.23
Ebov	2065.83	2031.3	1942.45	-0.02	-0.09	-0.06
Marv	2072.3	2094.61	2167.65	0.02	0.06	0.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material