RPS6KB1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| RPS6KB1 | S6K, PS6K, S6K1, STK14A, p70-S6K, p70 S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha,S6K1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | NM_003161 |  |
NONE |  |
 |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.
RPS6KB1 is well expressed in both human and the homolog in bat, where the bat gene expression is roughly 2-fold higher than the human gene expression. There are fluctuations in expression levels in all samples, but no clear pattern could be easily discerned.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 136 | 193 | 163 | 175 | 203 | 288 | 187 | 232 | 137 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 399 | 274 | 186 | 347 | 197 | 159 | 222 | 347 | 290 |
DESeq | | H. sapiens | Genome | 2327.91 | 2551.7 | 2348.04 | 2525.33 | 2510.58 | 3282.91 | 2393.14 | 2486.18 | 2032.16 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 3917.96 | 3109.52 | 2859.74 | 3975.61 | 3217.81 | 3208.7 | 4488.01 | 3125.0 | 3068.59 |