MDM2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MDM2 ACTFS,HDM2, MGC5370 MDM2 proto-oncogene, E3 ubiquitin protein ligase NM_006880 pdf

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Description

Homo sapiens MDM2 oncogene, E3 ubiquitin protein ligase (MDM2), transcript variant 1, mRNA. This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome604 373 409 323 607 330 439 426 425
Read_Max
batR. aegyptiacusTranscriptome 558 495 399 452 405 611 467 546 495
Read_Max
bat_genomeR. aegyptiacusGenome 689 500 350 598 348 362 415 665 538
DESeq
humanH. sapiensGenome 12130.75 7988.64 8767.64 8592.63 9480.01 6327.95 8402.87 7438.16 11718.25
DESeq
batR. aegyptiacusTranscriptome 4442.82 4140.07 4154.22 3949.36 4226.95 5131.16 5022.4 3962.67 3310.02
DESeq
bat_genomeR. aegyptiacusGenome 6508.16 5903.25 5672.61 6402.84 6164.41 7435.62 7668.18 5676.7 4817.79

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 12130.75 8592.63 8402.87 -0.5 -0.53 -0.03
7h 7988.64 9480.01 7438.16 0.25 -0.1 -0.35
23h 8767.64 6327.95 11718.25 -0.47 0.42 0.89

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 12130.75 7988.64 8767.64 -0.6 -0.47 0.13
Ebov 8592.63 9480.01 6327.95 0.14 -0.44 -0.58
Marv 8402.87 7438.16 11718.25 -0.18 0.48 0.66

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4442.82 3949.36 5022.4 -0.17 0.18 0.35
7h 4140.07 4226.95 3962.67 0.03 -0.06 -0.09
23h 4154.22 5131.16 3310.02 0.3 -0.33 -0.63

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4442.82 4140.07 4154.22 -0.1 -0.1 0.0
Ebov 3949.36 4226.95 5131.16 0.1 0.38 0.28
Marv 5022.4 3962.67 3310.02 -0.34 -0.6 -0.26