MDM2
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| MDM2 | ACTFS,HDM2, MGC5370 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | NM_006880 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Homo sapiens MDM2 oncogene, E3 ubiquitin protein ligase (MDM2), transcript variant 1, mRNA. This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013].
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 604 | 373 | 409 | 323 | 607 | 330 | 439 | 426 | 425 |
Read_Max |  | R. aegyptiacus | Transcriptome | 558 | 495 | 399 | 452 | 405 | 611 | 467 | 546 | 495 |
Read_Max |  | R. aegyptiacus | Genome | 689 | 500 | 350 | 598 | 348 | 362 | 415 | 665 | 538 |
DESeq | | H. sapiens | Genome | 12130.75 | 7988.64 | 8767.64 | 8592.63 | 9480.01 | 6327.95 | 8402.87 | 7438.16 | 11718.25 |
DESeq | | R. aegyptiacus | Transcriptome | 4442.82 | 4140.07 | 4154.22 | 3949.36 | 4226.95 | 5131.16 | 5022.4 | 3962.67 | 3310.02 |
DESeq | | R. aegyptiacus | Genome | 6508.16 | 5903.25 | 5672.61 | 6402.84 | 6164.41 | 7435.62 | 7668.18 | 5676.7 | 4817.79 |