ACTR2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ACTR2	Arp2,ARP2	ARP2 actin-related protein 2 homolog (yeast)	NM_001005386	pdf

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Description

The gene ACTR2 is expressed throughout human and bat datasets without significant changes in expression levels. The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	962	1123	1177	1001	1598	1318	1275	1641	913
Read_Max	R. aegyptiacus	Transcriptome	3190	2772	1486	2508	2242	2035	2822	3012	2175
Read_Max	R. aegyptiacus	Genome	3642	2623	1381	2820	1974	1252	2381	3495	2489
DESeq	H. sapiens	Genome	13600.16	13259.35	14905.28	14494.52	14527.62	13969.51	13709.08	12680.3	13411.25
DESeq	R. aegyptiacus	Transcriptome	23466.96	21673.0	14648.45	19070.71	19128.94	16541.21	24205.84	19325.19	14796.7
DESeq	R. aegyptiacus	Genome	34057.63	27232.69	19863.08	33774.9	28408.96	25515.54	36879.03	27627.82	22031.52

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	13600.16	14494.52	13709.08	0.09	0.01	-0.08
7h	13259.35	14527.62	12680.3	0.13	-0.06	-0.2
23h	14905.28	13969.51	13411.25	-0.09	-0.15	-0.06

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	13600.16	13259.35	14905.28	-0.04	0.13	0.17
Ebov	14494.52	14527.62	13969.51	0.0	-0.05	-0.06
Marv	13709.08	12680.3	13411.25	-0.11	-0.03	0.08

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	23466.96	19070.71	24205.84	-0.3	0.04	0.34
7h	21673.0	19128.94	19325.19	-0.18	-0.17	0.01
23h	14648.45	16541.21	14796.7	0.18	0.01	-0.16

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	23466.96	21673.0	14648.45	-0.11	-0.68	-0.57
Ebov	19070.71	19128.94	16541.21	0.0	-0.21	-0.21
Marv	24205.84	19325.19	14796.7	-0.32	-0.71	-0.39

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material