HECTD1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
HECTD1	EULIR, KIAA1131,KIAA1131	HECT domain containing E3 ubiquitin protein ligase 1		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity). After 7 hours of infection with Marburg virus, the expression is upregulated in bat. In contrast the expression is slightly downregulated 23 hours after Marburg virus infection in bat as well as Hu7.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	1361	1445	1071	1185	1594	1550	1408	1460	773
Read_Max	R. aegyptiacus	Transcriptome	551	461	275	499	424	483	419	567	430
Read_Max	R. aegyptiacus	Genome	630	534	228	470	359	275	361	647	465
DESeq	H. sapiens	Genome	47203.81	50975.27	46343.08	50573.19	55293.03	53607.72	45603.37	44532.01	35880.18
DESeq	R. aegyptiacus	Transcriptome	18928.52	15005.11	11771.73	17257.69	17863.01	18301.74	19032.04	15988.96	12918.7
DESeq	R. aegyptiacus	Genome	21373.03	18962.85	12281.37	17998.86	20276.8	20972.72	21578.65	17206.93	14339.5

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	47203.81	50573.19	45603.37	0.1	-0.05	-0.15
7h	50975.27	55293.03	44532.01	0.12	-0.19	-0.31
23h	46343.08	53607.72	35880.18	0.21	-0.37	-0.58

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	47203.81	50975.27	46343.08	0.11	-0.03	-0.14
Ebov	50573.19	55293.03	53607.72	0.13	0.08	-0.04
Marv	45603.37	44532.01	35880.18	-0.03	-0.35	-0.31

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	18928.52	17257.69	19032.04	-0.13	0.01	0.14
7h	15005.11	17863.01	15988.96	0.25	0.09	-0.16
23h	11771.73	18301.74	12918.7	0.64	0.13	-0.5

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	18928.52	15005.11	11771.73	-0.34	-0.69	-0.35
Ebov	17257.69	17863.01	18301.74	0.05	0.08	0.04
Marv	19032.04	15988.96	12918.7	-0.25	-0.56	-0.31

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material