NEK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NEK1 KIAA1901, NM_001199397, NP_001186326, Q96PY6-3,NY-REN-55, KIAA1901 NIMA-related kinase 1 pdf

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Description

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). This gene is not significantly differentially expressed. In all of the human probes the gene include a unknown transcript in one of the intronic regions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome40 66 61 51 88 68 55 64 74
Read_Max
batR. aegyptiacusTranscriptome 101 104 68 132 92 109 70 170 94
Read_Max
bat_genomeR. aegyptiacusGenome 111 122 56 95 77 57 72 192 107
DESeq
humanH. sapiensGenome 830.08 910.73 850.86 833.7 984.67 919.51 793.99 888.28 1349.31
DESeq
batR. aegyptiacusTranscriptome 1467.05 1216.4 1152.91 1858.89 1642.54 1467.68 1439.34 1893.02 1256.21
DESeq
bat_genomeR. aegyptiacusGenome 2074.57 2485.24 1543.12 1758.71 2269.1 1986.83 2036.53 2570.73 1784.3

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 830.08 833.7 793.99 0.01 -0.06 -0.07
7h 910.73 984.67 888.28 0.11 -0.04 -0.15
23h 850.86 919.51 1349.31 0.11 0.67 0.55

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 830.08 910.73 850.86 0.13 0.04 -0.1
Ebov 833.7 984.67 919.51 0.24 0.14 -0.1
Marv 793.99 888.28 1349.31 0.16 0.77 0.6

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1467.05 1858.89 1439.34 0.34 -0.03 -0.37
7h 1216.4 1642.54 1893.02 0.43 0.64 0.2
23h 1152.91 1467.68 1256.21 0.35 0.12 -0.22

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1467.05 1216.4 1152.91 -0.27 -0.35 -0.08
Ebov 1858.89 1642.54 1467.68 -0.18 -0.34 -0.16
Marv 1439.34 1893.02 1256.21 0.4 -0.2 -0.59