AR

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
AR	DHTR, SBMA, NR3C4, HYSP1, Androgen receptor,AIS, SMAX1, HUMARA	androgen receptor	NM_000044	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens androgen receptor (AR), transcript variant 1, mRNA. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	13	10	17	9	19	19	11	13	13
Read_Max	R. aegyptiacus	Transcriptome	4	4	5	2	2	5	4	7	2
Read_Max	R. aegyptiacus	Genome	6	3	4	5	4	3	5	5	8
DESeq	H. sapiens	Genome	2.01	6.1	1.0	1.0	1.81	1.0	1.0	4.2	1.0
DESeq	R. aegyptiacus	Transcriptome	11.08	14.62	10.77	4.66	5.38	8.7	15.46	10.91	3.62
DESeq	R. aegyptiacus	Genome	62.74	35.59	46.86	67.15	62.5	52.22	57.35	50.75	59.08

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2.01	1.0	1.0	-1.01	-1.01	0.0
7h	6.1	1.81	4.2	-1.75	-0.54	1.21
23h	1.0	1.0	1.0	0.0	0.0	0.0

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2.01	6.1	1.0	1.6	-1.01	-2.61
Ebov	1.0	1.81	1.0	0.86	0.0	-0.86
Marv	1.0	4.2	1.0	2.07	0.0	-2.07

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	11.08	4.66	15.46	-1.25	0.48	1.73
7h	14.62	5.38	10.91	-1.44	-0.42	1.02
23h	10.77	8.7	3.62	-0.31	-1.57	-1.27

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	11.08	14.62	10.77	0.4	-0.04	-0.44
Ebov	4.66	5.38	8.7	0.21	0.9	0.69
Marv	15.46	10.91	3.62	-0.5	-2.09	-1.59

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

AR