PYGL

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PYGL F5H816, F5H816_HUMAN, NM_001163940, NP_001157412 phosphorylase, glycogen, liver NM_002863 pdf NONE

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Description

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly.This gene is not significantly differentially expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome111 171 122 147 180 161 165 143 146
Read_Max
batR. aegyptiacusTranscriptome 25 18 25 30 23 15 15 17 40
Read_Max
bat_genomeR. aegyptiacusGenome 22 18 18 19 17 10 15 23 30
DESeq
humanH. sapiensGenome 1586.1 1932.64 1820.85 1583.13 1707.38 1834.08 1615.06 1610.09 1944.09
DESeq
batR. aegyptiacusTranscriptome 184.15 170.74 321.04 169.48 188.26 196.04 157.85 167.07 305.4
DESeq
bat_genomeR. aegyptiacusGenome 282.74 237.3 369.32 276.5 304.7 272.83 293.5 250.57 410.12

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1586.1 1583.13 1615.06 -0.0 0.03 0.03
7h 1932.64 1707.38 1610.09 -0.18 -0.26 -0.08
23h 1820.85 1834.08 1944.09 0.01 0.09 0.08

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1586.1 1932.64 1820.85 0.29 0.2 -0.09
Ebov 1583.13 1707.38 1834.08 0.11 0.21 0.1
Marv 1615.06 1610.09 1944.09 -0.0 0.27 0.27

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 184.15 169.48 157.85 -0.12 -0.22 -0.1
7h 170.74 188.26 167.07 0.14 -0.03 -0.17
23h 321.04 196.04 305.4 -0.71 -0.07 0.64

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 184.15 170.74 321.04 -0.11 0.8 0.91
Ebov 169.48 188.26 196.04 0.15 0.21 0.06
Marv 157.85 167.07 305.4 0.08 0.95 0.87