NUP214

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NUP214	A6NFQ0, CAIN, CAN, KIAA0023, NM_005085, NP_005076, NU214_HUMAN, P35658, Q15010, Q3KQZ0, Q5JUP7, Q75R47, Q86XD3,CAIN, D9S46E, N214	nucleoporin 214kDa	NM_005085	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. This gene is not significantly differentially expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	152	176	171	128	208	193	178	216	123
Read_Max	R. aegyptiacus	Transcriptome	86	81	56	85	70	67	70	85	75
Read_Max	R. aegyptiacus	Genome	93	65	47	78	48	38	60	102	81
DESeq	H. sapiens	Genome	4696.42	5115.66	4163.91	4439.4	4640.51	4647.52	4487.03	5062.49	3408.75
DESeq	R. aegyptiacus	Transcriptome	2066.07	1954.35	1708.71	1978.84	2067.43	1870.6	1912.11	1831.88	1558.86
DESeq	R. aegyptiacus	Genome	2279.96	1999.69	1882.32	2242.58	2030.25	2014.25	2072.51	1880.87	1730.36

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4696.42	4439.4	4487.03	-0.08	-0.07	0.02
7h	5115.66	4640.51	5062.49	-0.14	-0.02	0.13
23h	4163.91	4647.52	3408.75	0.16	-0.29	-0.45

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4696.42	5115.66	4163.91	0.12	-0.17	-0.3
Ebov	4439.4	4640.51	4647.52	0.06	0.07	0.0
Marv	4487.03	5062.49	3408.75	0.17	-0.4	-0.57

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2066.07	1978.84	1912.11	-0.06	-0.11	-0.05
7h	1954.35	2067.43	1831.88	0.08	-0.09	-0.17
23h	1708.71	1870.6	1558.86	0.13	-0.13	-0.26

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2066.07	1954.35	1708.71	-0.08	-0.27	-0.19
Ebov	1978.84	2067.43	1870.6	0.06	-0.08	-0.14
Marv	1912.11	1831.88	1558.86	-0.06	-0.29	-0.23

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material