IRF1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IRF1 MAR interferon regulatory factor 1 NM_002198 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.

upregulated in bats after 23 hrs ebola and marburg but same pattern in mock sample

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome7 10 8 13 7 11 8 7 10
Read_Max
batR. aegyptiacusTranscriptome 15 20 35 28 39 24 9 11 33
Read_Max
bat_genomeR. aegyptiacusGenome 28 28 46 19 23 34 15 32 69
DESeq
humanH. sapiensGenome 33.47 42.81 49.65 86.55 32.71 93.11 65.91 40.17 90.16
DESeq
batR. aegyptiacusTranscriptome 37.13 52.74 139.03 63.27 98.46 81.84 28.81 32.4 111.21
DESeq
bat_genomeR. aegyptiacusGenome 151.25 214.48 480.9 136.27 219.88 471.25 122.57 154.62 478.61

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 33.47 86.55 65.91 1.37 0.98 -0.39
7h 42.81 32.71 40.17 -0.39 -0.09 0.3
23h 49.65 93.11 90.16 0.91 0.86 -0.05

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 33.47 42.81 49.65 0.36 0.57 0.21
Ebov 86.55 32.71 93.11 -1.4 0.11 1.51
Marv 65.91 40.17 90.16 -0.71 0.45 1.17

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 37.13 63.27 28.81 0.77 -0.37 -1.13
7h 52.74 98.46 32.4 0.9 -0.7 -1.6
23h 139.03 81.84 111.21 -0.76 -0.32 0.44

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 37.13 52.74 139.03 0.51 1.9 1.4
Ebov 63.27 98.46 81.84 0.64 0.37 -0.27
Marv 28.81 32.4 111.21 0.17 1.95 1.78