YBX1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
YBX1	NSEP1, YB1,YB-1, DBPB, NSEP-1, MDR-NF1, BP-8, CSDB, CSDA2	Y box binding protein 1	NM_004559	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.YBX1 is very high expressed in all samples. In Hu7 expression decreases 23 hours after infection with Marburg virus. In contrast, the expression increases 7 and 23 hours after infection with Marburg virus in bat. Alternative splicing is promoted 23 hours after Ebola infection in Hu7 and not observed in this magnitude for all other Hu7 samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	3378	3543	2567	3360	3399	2717	4069	4765	2585
Read_Max	R. aegyptiacus	Transcriptome	4954	5111	4375	4030	3744	4784	3657	4740	6361
Read_Max	R. aegyptiacus	Genome	5372	4123	3717	4847	3099	2769	3020	5553	6982
DESeq	H. sapiens	Genome	10297.03	10298.66	8484.69	10793.0	8314.23	7372.8	10347.63	10744.27	9047.73
DESeq	R. aegyptiacus	Transcriptome	19539.31	22279.34	23748.9	17629.45	18728.13	21877.96	19426.95	17258.84	23284.0
DESeq	R. aegyptiacus	Genome	20792.94	17832.04	21954.04	24813.49	19272.28	22390.39	20224.71	16906.4	22644.56

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	10297.03	10793.0	10347.63	0.07	0.01	-0.06
7h	10298.66	8314.23	10744.27	-0.31	0.06	0.37
23h	8484.69	7372.8	9047.73	-0.2	0.09	0.3

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	10297.03	10298.66	8484.69	0.0	-0.28	-0.28
Ebov	10793.0	8314.23	7372.8	-0.38	-0.55	-0.17
Marv	10347.63	10744.27	9047.73	0.05	-0.19	-0.25

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	19539.31	17629.45	19426.95	-0.15	-0.01	0.14
7h	22279.34	18728.13	17258.84	-0.25	-0.37	-0.12
23h	23748.9	21877.96	23284.0	-0.12	-0.03	0.09

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	19539.31	22279.34	23748.9	0.19	0.28	0.09
Ebov	17629.45	18728.13	21877.96	0.09	0.31	0.22
Marv	19426.95	17258.84	23284.0	-0.17	0.26	0.43

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material