YBX1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
YBX1 NSEP1, YB1,YB-1, DBPB, NSEP-1, MDR-NF1, BP-8, CSDB, CSDA2 Y box binding protein 1 NM_004559 pdf

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Description

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.YBX1 is very high expressed in all samples. In Hu7 expression decreases 23 hours after infection with Marburg virus. In contrast, the expression increases 7 and 23 hours after infection with Marburg virus in bat. Alternative splicing is promoted 23 hours after Ebola infection in Hu7 and not observed in this magnitude for all other Hu7 samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome3378 3543 2567 3360 3399 2717 4069 4765 2585
Read_Max
batR. aegyptiacusTranscriptome 4954 5111 4375 4030 3744 4784 3657 4740 6361
Read_Max
bat_genomeR. aegyptiacusGenome 5372 4123 3717 4847 3099 2769 3020 5553 6982
DESeq
humanH. sapiensGenome 10297.03 10298.66 8484.69 10793.0 8314.23 7372.8 10347.63 10744.27 9047.73
DESeq
batR. aegyptiacusTranscriptome 19539.31 22279.34 23748.9 17629.45 18728.13 21877.96 19426.95 17258.84 23284.0
DESeq
bat_genomeR. aegyptiacusGenome 20792.94 17832.04 21954.04 24813.49 19272.28 22390.39 20224.71 16906.4 22644.56

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10297.03 10793.0 10347.63 0.07 0.01 -0.06
7h 10298.66 8314.23 10744.27 -0.31 0.06 0.37
23h 8484.69 7372.8 9047.73 -0.2 0.09 0.3

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10297.03 10298.66 8484.69 0.0 -0.28 -0.28
Ebov 10793.0 8314.23 7372.8 -0.38 -0.55 -0.17
Marv 10347.63 10744.27 9047.73 0.05 -0.19 -0.25

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 19539.31 17629.45 19426.95 -0.15 -0.01 0.14
7h 22279.34 18728.13 17258.84 -0.25 -0.37 -0.12
23h 23748.9 21877.96 23284.0 -0.12 -0.03 0.09

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 19539.31 22279.34 23748.9 0.19 0.28 0.09
Ebov 17629.45 18728.13 21877.96 0.09 0.31 0.22
Marv 19426.95 17258.84 23284.0 -0.17 0.26 0.43