LIMK2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
LIMK2		LIM domain kinase 2	NM_016733	pdf

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Description

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. The gene is lowly and uniformly expressed in humans. The bat homolog is more highly expressed and downregulated in MARV.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	23	22	17	26	23	28	34	30	27
Read_Max	R. aegyptiacus	Transcriptome	128	131	86	90	84	63	63	103	110
Read_Max	R. aegyptiacus	Genome	127	116	91	135	73	36	67	143	120
DESeq	H. sapiens	Genome	442.43	343.68	409.05	549.67	409.91	544.48	572.06	427.05	688.2
DESeq	R. aegyptiacus	Transcriptome	1010.01	1362.53	1222.54	856.23	897.88	575.87	764.11	949.49	878.33
DESeq	R. aegyptiacus	Genome	1862.3	1559.78	2208.12	2356.14	1685.36	1281.91	1566.47	1648.53	1540.29

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	442.43	549.67	572.06	0.31	0.37	0.06
7h	343.68	409.91	427.05	0.25	0.31	0.06
23h	409.05	544.48	688.2	0.41	0.75	0.34

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	442.43	343.68	409.05	-0.36	-0.11	0.25
Ebov	549.67	409.91	544.48	-0.42	-0.01	0.41
Marv	572.06	427.05	688.2	-0.42	0.27	0.69

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1010.01	856.23	764.11	-0.24	-0.4	-0.16
7h	1362.53	897.88	949.49	-0.6	-0.52	0.08
23h	1222.54	575.87	878.33	-1.09	-0.48	0.61

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1010.01	1362.53	1222.54	0.43	0.28	-0.16
Ebov	856.23	897.88	575.87	0.07	-0.57	-0.64
Marv	764.11	949.49	878.33	0.31	0.2	-0.11

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material