LIMK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
LIMK1 LIMK, LIMK-1 LIM domain kinase 1 NM_002314 pdf

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Description

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. The gene is uniformly expressed in human. The bat homolog is uniformly expressed, but the 3' end of MARV 7h is higher than in the other datasets.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome51 69 59 58 71 57 74 108 62
Read_Max
batR. aegyptiacusTranscriptome 105 123 110 74 84 161 83 141 226
Read_Max
bat_genomeR. aegyptiacusGenome 207 161 126 175 141 162 140 274 418
DESeq
humanH. sapiensGenome 918.37 921.95 811.14 913.55 690.38 587.9 965.93 998.59 875.23
DESeq
batR. aegyptiacusTranscriptome 818.46 857.86 1038.08 880.04 782.89 1108.39 873.13 928.01 1438.15
DESeq
bat_genomeR. aegyptiacusGenome 2101.21 2166.71 2371.03 2152.71 2108.38 2713.95 2225.45 2128.27 3584.02

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 918.37 913.55 965.93 -0.01 0.07 0.08
7h 921.95 690.38 998.59 -0.42 0.12 0.53
23h 811.14 587.9 875.23 -0.46 0.11 0.57

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 918.37 921.95 811.14 0.01 -0.18 -0.18
Ebov 913.55 690.38 587.9 -0.4 -0.64 -0.23
Marv 965.93 998.59 875.23 0.05 -0.14 -0.19

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 818.46 880.04 873.13 0.1 0.09 -0.01
7h 857.86 782.89 928.01 -0.13 0.11 0.25
23h 1038.08 1108.39 1438.15 0.09 0.47 0.38

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 818.46 857.86 1038.08 0.07 0.34 0.28
Ebov 880.04 782.89 1108.39 -0.17 0.33 0.5
Marv 873.13 928.01 1438.15 0.09 0.72 0.63