Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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SMAD1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
SMAD1	A8KAJ0, BSP1, D3DNZ9, MADH1, MADR1, NM_005900, NP_005891, Q15797, Q16636, SMAD1_HUMAN,MADR1, JV4-1	SMAD family member 1	NM_005900	pdf

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Description

Homo sapiens SMAD family member 1 (SMAD1), transcript variant 1 protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

In contrast to RAE, the human samples show a minor expression with nearly equal mapping results. The covered antisense located BC069804 and BC042377 cDNA clones show no expression pattern. In RAE the wildype expression decreases, while the ebola and marburg infected bat tissues shows an (ebola: slight 3-7h down- and then) upregulation of this gene homolog.

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