SMAD1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SMAD1 A8KAJ0, BSP1, D3DNZ9, MADH1, MADR1, NM_005900, NP_005891, Q15797, Q16636, SMAD1_HUMAN,MADR1, JV4-1 SMAD family member 1 NM_005900 pdf

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Description

Homo sapiens SMAD family member 1 (SMAD1), transcript variant 1 protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

In contrast to RAE, the human samples show a minor expression with nearly equal mapping results. The covered antisense located BC069804 and BC042377 cDNA clones show no expression pattern. In RAE the wildype expression decreases, while the ebola and marburg infected bat tissues shows an (ebola: slight 3-7h down- and then) upregulation of this gene homolog.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome87 76 81 63 103 120 101 108 77
Read_Max
batR. aegyptiacusTranscriptome 190 187 140 168 128 192 126 178 200
Read_Max
bat_genomeR. aegyptiacusGenome 209 173 116 180 114 113 111 214 217
DESeq
humanH. sapiensGenome 1220.77 902.57 1119.91 967.16 1169.21 1301.13 1109.79 949.03 1192.73
DESeq
batR. aegyptiacusTranscriptome 1293.14 1282.66 1366.68 1285.68 1268.02 1703.78 1164.58 1184.13 1325.31
DESeq
bat_genomeR. aegyptiacusGenome 2017.85 2064.49 2364.33 2129.01 2064.85 2896.7 2057.89 2028.36 2335.69

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1220.77 967.16 1109.79 -0.34 -0.14 0.2
7h 902.57 1169.21 949.03 0.37 0.07 -0.3
23h 1119.91 1301.13 1192.73 0.22 0.09 -0.13

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1220.77 902.57 1119.91 -0.44 -0.12 0.31
Ebov 967.16 1169.21 1301.13 0.27 0.43 0.15
Marv 1109.79 949.03 1192.73 -0.23 0.1 0.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1293.14 1285.68 1164.58 -0.01 -0.15 -0.14
7h 1282.66 1268.02 1184.13 -0.02 -0.12 -0.1
23h 1366.68 1703.78 1325.31 0.32 -0.04 -0.36

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1293.14 1282.66 1366.68 -0.01 0.08 0.09
Ebov 1285.68 1268.02 1703.78 -0.02 0.41 0.43
Marv 1164.58 1184.13 1325.31 0.02 0.19 0.16