ROCK1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ROCK1	p160ROCK	Rho-associated, coiled-coil containing protein kinase 1	NM_005406	pdf

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Description

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. The ROCK1 gene is expressed in all investigated cells of human and bats. In ebola and Marburg-Virus infected cells the expression is up-regulated after 7 hours and down-regulated after 23 hours.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	429	454	543	442	644	471	450	507	468
Read_Max	R. aegyptiacus	Transcriptome	613	476	391	616	579	617	586	740	617
Read_Max	R. aegyptiacus	Genome	657	623	315	444	457	373	494	897	683
DESeq	H. sapiens	Genome	10230.05	11187.99	12311.03	10125.7	12560.28	9853.31	9227.44	9754.67	12011.83
DESeq	R. aegyptiacus	Transcriptome	11660.47	9521.76	9687.79	11977.94	12453.27	13736.18	13300.93	12513.1	10904.24
DESeq	R. aegyptiacus	Genome	13325.7	13204.73	10028.61	11458.76	14294.33	15790.24	15202.55	13542.72	12147.65

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	10230.05	10125.7	9227.44	-0.01	-0.15	-0.13
7h	11187.99	12560.28	9754.67	0.17	-0.2	-0.36
23h	12311.03	9853.31	12011.83	-0.32	-0.04	0.29

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	10230.05	11187.99	12311.03	0.13	0.27	0.14
Ebov	10125.7	12560.28	9853.31	0.31	-0.04	-0.35
Marv	9227.44	9754.67	12011.83	0.08	0.38	0.3

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	11660.47	11977.94	13300.93	0.04	0.19	0.15
7h	9521.76	12453.27	12513.1	0.39	0.39	0.01
23h	9687.79	13736.18	10904.24	0.5	0.17	-0.33

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	11660.47	9521.76	9687.79	-0.29	-0.27	0.02
Ebov	11977.94	12453.27	13736.18	0.06	0.2	0.14
Marv	13300.93	12513.1	10904.24	-0.09	-0.29	-0.2

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material