ROCK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ROCK1 p160ROCK Rho-associated, coiled-coil containing protein kinase 1 NM_005406 pdf

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Description

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. The ROCK1 gene is expressed in all investigated cells of human and bats. In ebola and Marburg-Virus infected cells the expression is up-regulated after 7 hours and down-regulated after 23 hours.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome429 454 543 442 644 471 450 507 468
Read_Max
batR. aegyptiacusTranscriptome 613 476 391 616 579 617 586 740 617
Read_Max
bat_genomeR. aegyptiacusGenome 657 623 315 444 457 373 494 897 683
DESeq
humanH. sapiensGenome 10230.05 11187.99 12311.03 10125.7 12560.28 9853.31 9227.44 9754.67 12011.83
DESeq
batR. aegyptiacusTranscriptome 11660.47 9521.76 9687.79 11977.94 12453.27 13736.18 13300.93 12513.1 10904.24
DESeq
bat_genomeR. aegyptiacusGenome 13325.7 13204.73 10028.61 11458.76 14294.33 15790.24 15202.55 13542.72 12147.65

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10230.05 10125.7 9227.44 -0.01 -0.15 -0.13
7h 11187.99 12560.28 9754.67 0.17 -0.2 -0.36
23h 12311.03 9853.31 12011.83 -0.32 -0.04 0.29

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10230.05 11187.99 12311.03 0.13 0.27 0.14
Ebov 10125.7 12560.28 9853.31 0.31 -0.04 -0.35
Marv 9227.44 9754.67 12011.83 0.08 0.38 0.3

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 11660.47 11977.94 13300.93 0.04 0.19 0.15
7h 9521.76 12453.27 12513.1 0.39 0.39 0.01
23h 9687.79 13736.18 10904.24 0.5 0.17 -0.33

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 11660.47 9521.76 9687.79 -0.29 -0.27 0.02
Ebov 11977.94 12453.27 13736.18 0.06 0.2 0.14
Marv 13300.93 12513.1 10904.24 -0.09 -0.29 -0.2