PTK2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PTK2	FAK, FADK, FAK1, PPP1R71	protein tyrosine kinase 2	NM_005607	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

PTK2 is differentially expressed, but there are no strong up/downregulations.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	205	312	293	219	386	328	278	367	329
Read_Max	R. aegyptiacus	Transcriptome	200	194	164	233	216	204	129	241	238
Read_Max	R. aegyptiacus	Genome	276	244	173	208	190	162	186	285	403
DESeq	H. sapiens	Genome	4396.04	5378.79	6014.54	4908.22	5633.94	6459.55	4797.56	4993.74	6177.13
DESeq	R. aegyptiacus	Transcriptome	2406.32	2444.5	2637.08	2667.43	2824.14	2965.15	2329.27	2565.55	2781.7
DESeq	R. aegyptiacus	Genome	5706.35	5581.98	6093.26	5663.22	6019.31	7332.49	5511.33	5608.51	6646.62

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4396.04	4908.22	4797.56	0.16	0.13	-0.03
7h	5378.79	5633.94	4993.74	0.07	-0.11	-0.17
23h	6014.54	6459.55	6177.13	0.1	0.04	-0.06

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4396.04	5378.79	6014.54	0.29	0.45	0.16
Ebov	4908.22	5633.94	6459.55	0.2	0.4	0.2
Marv	4797.56	4993.74	6177.13	0.06	0.36	0.31

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2406.32	2667.43	2329.27	0.15	-0.05	-0.2
7h	2444.5	2824.14	2565.55	0.21	0.07	-0.14
23h	2637.08	2965.15	2781.7	0.17	0.08	-0.09

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2406.32	2444.5	2637.08	0.02	0.13	0.11
Ebov	2667.43	2824.14	2965.15	0.08	0.15	0.07
Marv	2329.27	2565.55	2781.7	0.14	0.26	0.12

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material