COL3A1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
COL3A1 EDS4A collagen, type III, alpha 1 NM_000090 pdf

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Description

The gene COL3A1 is almost not expressed in human but strongly expressed in bat throughout all datasets. While expression first goes down and then increases in bat ebola infected cells, it increases first and then goes down in marburg infected cells.

This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (provided by R. Dalgleish, Feb 2008)

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome11 9 10 10 18 10 8 13 10
Read_Max
batR. aegyptiacusTranscriptome 1004 938 866 844 684 700 715 1030 1041
Read_Max
bat_genomeR. aegyptiacusGenome 1878 1337 1137 1725 966 587 817 1984 1508
DESeq
humanH. sapiensGenome 144.08 113.19 113.19 112.79 149.77 78.64 124.69 142.49 78.2
DESeq
batR. aegyptiacusTranscriptome 20425.65 21204.63 24839.73 20642.0 20127.66 18082.31 21269.09 21575.78 19650.46
DESeq
bat_genomeR. aegyptiacusGenome 21140.14 20534.5 22912.5 23369.79 20698.7 18444.14 22106.05 21122.5 18897.86

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 144.08 112.79 124.69 -0.35 -0.21 0.14
7h 113.19 149.77 142.49 0.4 0.33 -0.07
23h 113.19 78.64 78.2 -0.53 -0.53 -0.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 144.08 113.19 113.19 -0.35 -0.35 0.0
Ebov 112.79 149.77 78.64 0.41 -0.52 -0.93
Marv 124.69 142.49 78.2 0.19 -0.67 -0.87

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 20425.65 20642.0 21269.09 0.02 0.06 0.04
7h 21204.63 20127.66 21575.78 -0.08 0.03 0.1
23h 24839.73 18082.31 19650.46 -0.46 -0.34 0.12

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 20425.65 21204.63 24839.73 0.05 0.28 0.23
Ebov 20642.0 20127.66 18082.31 -0.04 -0.19 -0.15
Marv 21269.09 21575.78 19650.46 0.02 -0.11 -0.13