MALT1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MALT1		MALT1 paracaspase		pdf

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Description

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. MALT-1 has an alternativly spliced isoform, in which the 6th exon is missing. This is especially observed in the transcriptome data of Hu7 23 hours after infection with Ebola virus. 7 hours after Marburg infection, the expression decreases in Hu7, while it rises again to the 3 hour level in the 23 hours Ebola sample. The expression of MALT1 also changes slightly after infection with Marburg and Ebola virus in bat, but no clear trends are visible.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	112	118	94	92	147	128	121	143	91
Read_Max	R. aegyptiacus	Transcriptome	137	143	93	162	128	217	82	143	151
Read_Max	R. aegyptiacus	Genome	162	170	88	149	115	140	77	190	178
DESeq	H. sapiens	Genome	1809.35	1654.21	1490.24	1693.77	1829.33	1886.72	1622.07	1558.93	1797.3
DESeq	R. aegyptiacus	Transcriptome	1408.24	1329.86	1383.78	1543.9	1482.66	2834.27	1355.91	1353.5	1775.78
DESeq	R. aegyptiacus	Genome	2100.35	2171.28	2239.37	1948.31	2307.05	4061.13	2046.65	2186.95	2869.1

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1809.35	1693.77	1622.07	-0.1	-0.16	-0.06
7h	1654.21	1829.33	1558.93	0.15	-0.09	-0.23
23h	1490.24	1886.72	1797.3	0.34	0.27	-0.07

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1809.35	1654.21	1490.24	-0.13	-0.28	-0.15
Ebov	1693.77	1829.33	1886.72	0.11	0.16	0.04
Marv	1622.07	1558.93	1797.3	-0.06	0.15	0.21

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1408.24	1543.9	1355.91	0.13	-0.05	-0.19
7h	1329.86	1482.66	1353.5	0.16	0.03	-0.13
23h	1383.78	2834.27	1775.78	1.03	0.36	-0.67

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1408.24	1329.86	1383.78	-0.08	-0.03	0.06
Ebov	1543.9	1482.66	2834.27	-0.06	0.88	0.93
Marv	1355.91	1353.5	1775.78	-0.0	0.39	0.39

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material