CALD1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CALD1	CAD, LCAD,CDM, H-CAD, L-CAD	caldesmon 1	NM_033138	pdf		NONE

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Description

The gene CALD1 is well expressed in human and very well expressed in bat datatsets. Furthermore expression levels in human in general rise while they decrease in bat for the ebola dataset. This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Jul 2008)

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	1561	1980	2196	1617	2942	2861	2181	2542	2455
Read_Max	R. aegyptiacus	Transcriptome	7037	6274	5256	7231	5118	4673	5389	7485	7059
Read_Max	R. aegyptiacus	Genome	15588	15669	8140	11152	9057	4854	8723	18320	13157
DESeq	H. sapiens	Genome	20081.6	23223.51	25881.95	23186.52	27647.02	32367.42	24590.81	23919.96	31317.68
DESeq	R. aegyptiacus	Transcriptome	56579.42	50242.54	59313.94	56523.37	54555.1	42358.83	57219.83	58054.54	51793.38
DESeq	R. aegyptiacus	Genome	137983.67	144906.98	130619.64	133952.15	146244.79	110688.32	147881.59	142885.69	128919.35

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	20081.6	23186.52	24590.81	0.21	0.29	0.08
7h	23223.51	27647.02	23919.96	0.25	0.04	-0.21
23h	25881.95	32367.42	31317.68	0.32	0.28	-0.05

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	20081.6	23223.51	25881.95	0.21	0.37	0.16
Ebov	23186.52	27647.02	32367.42	0.25	0.48	0.23
Marv	24590.81	23919.96	31317.68	-0.04	0.35	0.39

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	56579.42	56523.37	57219.83	-0.0	0.02	0.02
7h	50242.54	54555.1	58054.54	0.12	0.21	0.09
23h	59313.94	42358.83	51793.38	-0.49	-0.2	0.29

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	56579.42	50242.54	59313.94	-0.17	0.07	0.24
Ebov	56523.37	54555.1	42358.83	-0.05	-0.42	-0.37
Marv	57219.83	58054.54	51793.38	0.02	-0.14	-0.16

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material