TXN

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TXN TRX, B1ALW1, B1ALW1_HUMAN, hCG_28763, NM_001244938, NP_001231867, RP11-427L11.1-002 thioredoxin pdf

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Description

The Homo sapiens thioredoxin (TXN), transcript variant 2 protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Both species Human and Bat show an expression of this gene, whereof the level in RAE is much higher. The HG19 samples for MOCK show an upregulation between both timepoints 3 to 7h and 7 to 23h. During ebola infection first the transcription was increased two fold and is afterwards downregulated. The marburg infection shows straight upregulation up to two fold from 7h to 23h. I contrast the behaviour of expression profiles changes in the RAE samples. For MOCK the transcripts decrease, infected by ebola, they decrease first and increase again after 7h and during the marburg infection the gene is up-, then even two fold upregulated.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome508 546 854 563 1012 783 713 793 1257
Read_Max
batR. aegyptiacusTranscriptome 943 985 826 816 882 1180 944 1141 1702
Read_Max
bat_genomeR. aegyptiacusGenome 991 821 703 868 674 684 815 1347 1878
DESeq
humanH. sapiensGenome 2002.16 1777.62 2621.06 1988.07 2284.58 1663.01 2181.73 2195.22 4174.24
DESeq
batR. aegyptiacusTranscriptome 1926.6 2065.99 2257.18 2009.06 2356.54 2707.23 2549.52 2243.33 3215.55
DESeq
bat_genomeR. aegyptiacusGenome 2945.99 3071.18 3144.26 2938.75 3607.34 3929.28 3424.2 3408.87 4858.89

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2002.16 1988.07 2181.73 -0.01 0.12 0.13
7h 1777.62 2284.58 2195.22 0.36 0.3 -0.06
23h 2621.06 1663.01 4174.24 -0.66 0.67 1.33

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2002.16 1777.62 2621.06 -0.17 0.39 0.56
Ebov 1988.07 2284.58 1663.01 0.2 -0.26 -0.46
Marv 2181.73 2195.22 4174.24 0.01 0.94 0.93

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1926.6 2009.06 2549.52 0.06 0.4 0.34
7h 2065.99 2356.54 2243.33 0.19 0.12 -0.07
23h 2257.18 2707.23 3215.55 0.26 0.51 0.25

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1926.6 2065.99 2257.18 0.1 0.23 0.13
Ebov 2009.06 2356.54 2707.23 0.23 0.43 0.2
Marv 2549.52 2243.33 3215.55 -0.18 0.33 0.52