NEK6

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NEK6	SID6-1512	NIMA-related kinase 6	NM_014397	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. Expression of NEK6 is downregulated 23 hours after Marburg virus infection. All other Hu7 samples have an equal, moderate expression. NEK7 is only very low expressed in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	116	167	162	146	164	140	154	176	113
Read_Max	R. aegyptiacus	Transcriptome	3	3	5	1	2	4	6	2	9
Read_Max	R. aegyptiacus	Genome	3	3	5	5	4	5	4	4	8
DESeq	H. sapiens	Genome	1641.91	2014.23	1846.66	1926.47	1913.87	1564.32	1840.5	1822.72	1742.93
DESeq	R. aegyptiacus	Transcriptome	4.36	6.45	26.65	1.92	3.19	6.13	18.8	4.3	17.62
DESeq	R. aegyptiacus	Genome	37.81	20.08	108.23	43.45	32.37	60.05	32.61	26.17	74.49

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1641.91	1926.47	1840.5	0.23	0.16	-0.07
7h	2014.23	1913.87	1822.72	-0.07	-0.14	-0.07
23h	1846.66	1564.32	1742.93	-0.24	-0.08	0.16

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1641.91	2014.23	1846.66	0.29	0.17	-0.13
Ebov	1926.47	1913.87	1564.32	-0.01	-0.3	-0.29
Marv	1840.5	1822.72	1742.93	-0.01	-0.08	-0.06

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4.36	1.92	18.8	-1.18	2.11	3.29
7h	6.45	3.19	4.3	-1.02	-0.58	0.43
23h	26.65	6.13	17.62	-2.12	-0.6	1.52

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4.36	6.45	26.65	0.56	2.61	2.05
Ebov	1.92	3.19	6.13	0.73	1.67	0.94
Marv	18.8	4.3	17.62	-2.13	-0.09	2.03

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material