TNIP2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TNIP2 ABIN2, B1AKS4, B3KTY8, D3DVQ9, FLIP1, NM_001161527, NP_001154999, Q7L5L2, Q8NFZ5, Q9BQR6, Q9H682, TNIP2_HUMAN,ABIN-2, MGC4289, KLIP TNFAIP3 interacting protein 2 NM_024309 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens TNFAIP3 interacting protein 2 (TNIP2), transcript variant 2 gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome. TNIP2 inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

The hg19 samples show expression with transcripts in each intron, whereas rae samples are minor expressed. The hg19 intron MOCK expressions show an upregulation as of 7h, while intronic ebola and marburg infected sample expressions are upregulated from the starting timepoint. After 23h only the transcripts for marburg infected RAE were decreased. Regarding the exonic transcripts increased for all hg19 samples from 3 to 7h. Later MOCK and Marburg infected RAE transcripts decrease, while the ebola infected still rise. From RAE gene expression analysis we observe a downregulation for MOCK and Ebola from 3 to 7h and a two fold upregulation for Marburg infected samples. After 23h all samples show an upregulation in comparison to the 7h sequencing and read mapping results. For ebola the increase is even 3 fold.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome92 103 79 101 152 213 144 191 113
Read_Max
batR. aegyptiacusTranscriptome 17 18 28 10 10 30 12 20 30
Read_Max
bat_genomeR. aegyptiacusGenome 21 19 28 18 14 19 12 25 35
DESeq
humanH. sapiensGenome 836.17 950.5 811.14 923.81 911.5 1426.14 977.33 1009.78 1087.26
DESeq
batR. aegyptiacusTranscriptome 58.97 89.05 134.15 56.86 71.09 158.83 54.4 85.27 158.45
DESeq
bat_genomeR. aegyptiacusGenome 311.96 330.39 415.07 284.4 286.85 503.89 237.28 348.9 437.51

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 836.17 923.81 977.33 0.14 0.23 0.08
7h 950.5 911.5 1009.78 -0.06 0.09 0.15
23h 811.14 1426.14 1087.26 0.81 0.42 -0.39

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 836.17 950.5 811.14 0.18 -0.04 -0.23
Ebov 923.81 911.5 1426.14 -0.02 0.63 0.65
Marv 977.33 1009.78 1087.26 0.05 0.15 0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 58.97 56.86 54.4 -0.05 -0.12 -0.06
7h 89.05 71.09 85.27 -0.32 -0.06 0.26
23h 134.15 158.83 158.45 0.24 0.24 -0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 58.97 89.05 134.15 0.59 1.19 0.59
Ebov 56.86 71.09 158.83 0.32 1.48 1.16
Marv 54.4 85.27 158.45 0.65 1.54 0.89