PXN

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PXN AK128712, E7EMK8, E7EMK8_HUMAN, NM_025157, NP_079433 paxillin NM_002859 pdf NONE

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Description

The Homo sapiens paxillin (PXN), transcript variant 3 gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties.

The hg19 negativ strand annotated gene with equal expression patter for MOCK, upregulation in Ebola and up- (3-7h) and downregulation (7-23h) PXN shows at its 3' UTR an antisense ncRNA, which is strongly and differntial expressed for MOCK upregulated, ebola infected tissue two times two fold upregulated and marburg infected slight upregulated from 3 to 7h only. This suggest a direct regulatory function (Wutr:uu, Eutr:2u2u, Mutr:ue vs. W:ee, E:uu, M:ud). Furthermore the 5th or 6th intron shows to be trancribed with differential mapping results of MOCK downregulation beginning from the 7h sample, ebola infected upregulation from 3 to 7h and 7 to 23h and marburg infected first up- then downregulation. The homolog sequence in RAE is very strong expressed over all samples. The MOCK shows two times downregulation, whereas the ebola induced expression is first down- (3-7h) and later (7-23h) upregulated. The gene in marburg infected RAE tissue is two times upregulated.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome90 92 106 87 121 216 120 132 105
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 2187.87 2079.5 1715.61 2099.86 1855.34 2656.53 2115.06 2303.13 1827.74
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2187.87 2099.86 2115.06 -0.06 -0.05 0.01
7h 2079.5 1855.34 2303.13 -0.16 0.15 0.31
23h 1715.61 2656.53 1827.74 0.63 0.09 -0.54

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2187.87 2079.5 1715.61 -0.07 -0.35 -0.28
Ebov 2099.86 1855.34 2656.53 -0.18 0.34 0.52
Marv 2115.06 2303.13 1827.74 0.12 -0.21 -0.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA