SPIRE1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SPIRE1	AL833817, NM_001128627,spir-1, KIAA1135	spire-type actin nucleation factor 1	XM_290818	pdf				NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens spire homolog 1 (Drosophila) (SPIRE1), transcript variant 3 is a Spire protein which re highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization.

This gene in hg19 and the RAE transcriptome is nearly equal strong expressed. Between each of the 3 timepoint samples for human and bat, the differential expression is very weak. In HG19 MOCK and marburg samples the expression doesn't change, in contrast to a slight upregulation during ebola infection. For RAE sequencing, all samples show a downregulation between 3 and 7h. For 7 to 23h, the MOCK sample reads decreased, the ebola sample shows equal expression to 3-7h and during the marburg infection, the gene expression is upregulated.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	54	67	58	73	81	119	67	73	77
Read_Max	R. aegyptiacus	Transcriptome	260	267	143	207	187	220	220	204	236
Read_Max	R. aegyptiacus	Genome	NA	NA	NA	NA	NA	NA	NA	NA	NA
DESeq	H. sapiens	Genome	1114.22	1117.76	1214.23	1294.53	1179.78	1870.93	1251.02	1052.95	1634.2
DESeq	R. aegyptiacus	Transcriptome	1750.17	1769.18	1391.11	1407.47	1575.74	1793.6	1886.53	1476.61	1465.26
DESeq	R. aegyptiacus	Genome	NA	NA	NA	NA	NA	NA	NA	NA	NA

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1114.22	1294.53	1251.02	0.22	0.17	-0.05
7h	1117.76	1179.78	1052.95	0.08	-0.09	-0.16
23h	1214.23	1870.93	1634.2	0.62	0.43	-0.2

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1114.22	1117.76	1214.23	0.0	0.12	0.12
Ebov	1294.53	1179.78	1870.93	-0.13	0.53	0.67
Marv	1251.02	1052.95	1634.2	-0.25	0.39	0.63

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1750.17	1407.47	1886.53	-0.31	0.11	0.42
7h	1769.18	1575.74	1476.61	-0.17	-0.26	-0.09
23h	1391.11	1793.6	1465.26	0.37	0.07	-0.29

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1750.17	1769.18	1391.11	0.02	-0.33	-0.35
Ebov	1407.47	1575.74	1793.6	0.16	0.35	0.19
Marv	1886.53	1476.61	1465.26	-0.35	-0.36	-0.01

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material