NOD1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NOD1	CARD4,NLRC1, CLR7.1	nucleotide-binding oligomerization domain containing 1		pdf

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Description

Homo sapiens nucleotide-binding oligomerization domain containing 1 (NOD1), mRNA. This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	49	33	44	28	36	36	41	36	30
Read_Max	R. aegyptiacus	Transcriptome	80	70	49	69	61	115	61	90	79
Read_Max	R. aegyptiacus	Genome	88	78	45	72	54	79	56	115	93
DESeq	H. sapiens	Genome	106.54	57.09	92.34	95.68	78.23	45.74	54.51	72.94	91.25
DESeq	R. aegyptiacus	Transcriptome	932.72	927.75	884.17	976.19	1065.43	1570.33	917.62	899.91	966.68
DESeq	R. aegyptiacus	Genome	1635.42	1626.4	1682.59	1614.54	1867.29	3001.14	1602.46	1620.78	1718.38

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	106.54	95.68	54.51	-0.16	-0.97	-0.81
7h	57.09	78.23	72.94	0.45	0.35	-0.1
23h	92.34	45.74	91.25	-1.01	-0.02	1.0

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	106.54	57.09	92.34	-0.9	-0.21	0.69
Ebov	95.68	78.23	45.74	-0.29	-1.06	-0.77
Marv	54.51	72.94	91.25	0.42	0.74	0.32

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	932.72	976.19	917.62	0.07	-0.02	-0.09
7h	927.75	1065.43	899.91	0.2	-0.04	-0.24
23h	884.17	1570.33	966.68	0.83	0.13	-0.7

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	932.72	927.75	884.17	-0.01	-0.08	-0.07
Ebov	976.19	1065.43	1570.33	0.13	0.69	0.56
Marv	917.62	899.91	966.68	-0.03	0.08	0.1

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material