NOD1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NOD1 CARD4,NLRC1, CLR7.1 nucleotide-binding oligomerization domain containing 1 pdf

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Description

Homo sapiens nucleotide-binding oligomerization domain containing 1 (NOD1), mRNA. This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome49 33 44 28 36 36 41 36 30
Read_Max
batR. aegyptiacusTranscriptome 80 70 49 69 61 115 61 90 79
Read_Max
bat_genomeR. aegyptiacusGenome 88 78 45 72 54 79 56 115 93
DESeq
humanH. sapiensGenome 106.54 57.09 92.34 95.68 78.23 45.74 54.51 72.94 91.25
DESeq
batR. aegyptiacusTranscriptome 932.72 927.75 884.17 976.19 1065.43 1570.33 917.62 899.91 966.68
DESeq
bat_genomeR. aegyptiacusGenome 1635.42 1626.4 1682.59 1614.54 1867.29 3001.14 1602.46 1620.78 1718.38

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 106.54 95.68 54.51 -0.16 -0.97 -0.81
7h 57.09 78.23 72.94 0.45 0.35 -0.1
23h 92.34 45.74 91.25 -1.01 -0.02 1.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 106.54 57.09 92.34 -0.9 -0.21 0.69
Ebov 95.68 78.23 45.74 -0.29 -1.06 -0.77
Marv 54.51 72.94 91.25 0.42 0.74 0.32

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 932.72 976.19 917.62 0.07 -0.02 -0.09
7h 927.75 1065.43 899.91 0.2 -0.04 -0.24
23h 884.17 1570.33 966.68 0.83 0.13 -0.7

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 932.72 927.75 884.17 -0.01 -0.08 -0.07
Ebov 976.19 1065.43 1570.33 0.13 0.69 0.56
Marv 917.62 899.91 966.68 -0.03 0.08 0.1