BCL10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
BCL10 CARMEN, CIPER, mE10, c-E10, CLAP B-cell CLL/lymphoma 10 NM_003921 pdf

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Description

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. It is constantly expressed in human but in bat it is upregulated after 23 hours of ebola virus infection and after 7 and 23 hours of marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome72 53 56 56 80 99 60 79 82
Read_Max
batR. aegyptiacusTranscriptome 129 122 108 137 147 181 109 188 185
Read_Max
bat_genomeR. aegyptiacusGenome 158 112 96 118 107 100 100 207 211
DESeq
humanH. sapiensGenome 529.7 367.13 404.09 408.22 374.14 672.12 442.23 385.49 490.31
DESeq
batR. aegyptiacusTranscriptome 506.76 477.54 559.24 534.83 605.49 763.21 557.2 544.65 678.9
DESeq
bat_genomeR. aegyptiacusGenome 776.03 810.46 913.82 753.45 888.44 1217.95 912.0 893.65 1087.36

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 529.7 408.22 442.23 -0.38 -0.26 0.12
7h 367.13 374.14 385.49 0.03 0.07 0.04
23h 404.09 672.12 490.31 0.73 0.28 -0.46

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 529.7 367.13 404.09 -0.53 -0.39 0.14
Ebov 408.22 374.14 672.12 -0.13 0.72 0.85
Marv 442.23 385.49 490.31 -0.2 0.15 0.35

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 506.76 534.83 557.2 0.08 0.14 0.06
7h 477.54 605.49 544.65 0.34 0.19 -0.15
23h 559.24 763.21 678.9 0.45 0.28 -0.17

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 506.76 477.54 559.24 -0.09 0.14 0.23
Ebov 534.83 605.49 763.21 0.18 0.51 0.33
Marv 557.2 544.65 678.9 -0.03 0.29 0.32