BCL10

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
BCL10	CARMEN, CIPER, mE10, c-E10, CLAP	B-cell CLL/lymphoma 10	NM_003921	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. It is constantly expressed in human but in bat it is upregulated after 23 hours of ebola virus infection and after 7 and 23 hours of marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	72	53	56	56	80	99	60	79	82
Read_Max	R. aegyptiacus	Transcriptome	129	122	108	137	147	181	109	188	185
Read_Max	R. aegyptiacus	Genome	158	112	96	118	107	100	100	207	211
DESeq	H. sapiens	Genome	529.7	367.13	404.09	408.22	374.14	672.12	442.23	385.49	490.31
DESeq	R. aegyptiacus	Transcriptome	506.76	477.54	559.24	534.83	605.49	763.21	557.2	544.65	678.9
DESeq	R. aegyptiacus	Genome	776.03	810.46	913.82	753.45	888.44	1217.95	912.0	893.65	1087.36

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	529.7	408.22	442.23	-0.38	-0.26	0.12
7h	367.13	374.14	385.49	0.03	0.07	0.04
23h	404.09	672.12	490.31	0.73	0.28	-0.46

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	529.7	367.13	404.09	-0.53	-0.39	0.14
Ebov	408.22	374.14	672.12	-0.13	0.72	0.85
Marv	442.23	385.49	490.31	-0.2	0.15	0.35

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	506.76	534.83	557.2	0.08	0.14	0.06
7h	477.54	605.49	544.65	0.34	0.19	-0.15
23h	559.24	763.21	678.9	0.45	0.28	-0.17

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	506.76	477.54	559.24	-0.09	0.14	0.23
Ebov	534.83	605.49	763.21	0.18	0.51	0.33
Marv	557.2	544.65	678.9	-0.03	0.29	0.32

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material