PELI1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PELI1 pellino E3 ubiquitin protein ligase 1 NM_020651 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

PELI1 encodes for the pellino E3 ubiquitin protein ligase 1 protein. It catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. In the human mock probes it seems to be downregulated but upregulated after ebola virus and marburg virus infection. In bat it is constantly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome185 151 137 139 173 197 167 202 151
Read_Max
batR. aegyptiacusTranscriptome 111 87 56 69 50 73 71 81 82
Read_Max
bat_genomeR. aegyptiacusGenome 101 70 52 78 48 44 64 91 83
DESeq
humanH. sapiensGenome 1949.39 1842.89 2037.28 1851.19 1827.7 2223.59 1815.06 2033.75 2294.21
DESeq
batR. aegyptiacusTranscriptome 715.12 650.91 567.79 607.17 432.47 527.1 737.41 586.78 495.21
DESeq
bat_genomeR. aegyptiacusGenome 1002.91 835.11 774.35 937.12 727.72 882.46 1167.26 848.45 732.9

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1949.39 1851.19 1815.06 -0.07 -0.1 -0.03
7h 1842.89 1827.7 2033.75 -0.01 0.14 0.15
23h 2037.28 2223.59 2294.21 0.13 0.17 0.05

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1949.39 1842.89 2037.28 -0.08 0.06 0.14
Ebov 1851.19 1827.7 2223.59 -0.02 0.26 0.28
Marv 1815.06 2033.75 2294.21 0.16 0.34 0.17

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 715.12 607.17 737.41 -0.24 0.04 0.28
7h 650.91 432.47 586.78 -0.59 -0.15 0.44
23h 567.79 527.1 495.21 -0.11 -0.2 -0.09

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 715.12 650.91 567.79 -0.14 -0.33 -0.2
Ebov 607.17 432.47 527.1 -0.49 -0.2 0.29
Marv 737.41 586.78 495.21 -0.33 -0.57 -0.24