PIK3R2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PIK3R2 MPPH, MPPH1, P85B, p85, p85-BETA,P85B phosphoinositide-3-kinase, regulatory subunit 2 (beta) NM_005027 pdf

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Description

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. The gene is slightly downregulated in human EBOV 23h. Bat homolog is divergently upregulated in MARV 23h and downregulated in EBOV 7h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome267 264 250 260 289 244 296 320 200
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 291 209 220 272 136 126 174 257 355
DESeq
humanH. sapiensGenome 4153.51 3876.52 3599.99 4026.47 3360.11 3092.1 3949.3 4039.32 3009.69
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 3813.97 3267.41 4573.57 4212.6 3278.09 3417.56 3831.28 3079.01 4286.95

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4153.51 4026.47 3949.3 -0.04 -0.07 -0.03
7h 3876.52 3360.11 4039.32 -0.21 0.06 0.27
23h 3599.99 3092.1 3009.69 -0.22 -0.26 -0.04

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4153.51 3876.52 3599.99 -0.1 -0.21 -0.11
Ebov 4026.47 3360.11 3092.1 -0.26 -0.38 -0.12
Marv 3949.3 4039.32 3009.69 0.03 -0.39 -0.42

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA