PIK3R1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PIK3R1 AGM7, GRB1, p85, p85-ALPHA,GRB1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) NM_181504 pdf

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Description

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. The gene is slightly downregulated in human EBOV 23h. The bat homolog is uniformly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome95 98 81 100 125 78 101 104 79
Read_Max
batR. aegyptiacusTranscriptome 57 67 42 57 49 66 47 68 68
Read_Max
bat_genomeR. aegyptiacusGenome 78 57 38 58 41 35 41 73 74
DESeq
humanH. sapiensGenome 2067.11 1990.77 2103.8 2288.07 2265.07 1620.9 1923.83 1751.58 2234.41
DESeq
batR. aegyptiacusTranscriptome 624.38 678.14 529.93 575.12 572.64 601.53 598.36 558.69 577.43
DESeq
bat_genomeR. aegyptiacusGenome 1035.57 888.04 853.57 1134.62 946.48 1016.91 1023.32 938.85 976.06

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2067.11 2288.07 1923.83 0.15 -0.1 -0.25
7h 1990.77 2265.07 1751.58 0.19 -0.18 -0.37
23h 2103.8 1620.9 2234.41 -0.38 0.09 0.46

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2067.11 1990.77 2103.8 -0.05 0.03 0.08
Ebov 2288.07 2265.07 1620.9 -0.01 -0.5 -0.48
Marv 1923.83 1751.58 2234.41 -0.14 0.22 0.35

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 624.38 575.12 598.36 -0.12 -0.06 0.06
7h 678.14 572.64 558.69 -0.24 -0.28 -0.04
23h 529.93 601.53 577.43 0.18 0.12 -0.06

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 624.38 678.14 529.93 0.12 -0.24 -0.36
Ebov 575.12 572.64 601.53 -0.01 0.06 0.07
Marv 598.36 558.69 577.43 -0.1 -0.05 0.05