NFKBIB
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| NFKBIB | IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | NM_002503 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene. This gene is moderate in expression and slightly up-regulated after 23 hours in ebola infected human cells, but not in bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 23 | 33 | 41 | 39 | 42 | 159 | 34 | 49 | 27 |
Read_Max |  | R. aegyptiacus | Transcriptome | 44 | 55 | 54 | 49 | 60 | 63 | 44 | 54 | 54 |
Read_Max |  | R. aegyptiacus | Genome | 61 | 46 | 79 | 54 | 45 | 49 | 37 | 100 | 84 |
DESeq | | H. sapiens | Genome | 289.2 | 299.82 | 288.92 | 314.69 | 252.2 | 1681.43 | 284.34 | 383.89 | 320.68 |
DESeq | | R. aegyptiacus | Transcriptome | 235.4 | 299.63 | 345.47 | 225.34 | 262.73 | 347.46 | 273.54 | 201.77 | 273.03 |
DESeq | | R. aegyptiacus | Genome | 379.85 | 428.05 | 666.12 | 436.47 | 415.2 | 575.69 | 404.83 | 480.53 | 542.83 |