MAP3K10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAP3K10 MLK2, MKN28 Kinase,MST, MEKK10 mitogen-activated protein kinase kinase kinase 10 NM_002446 pdf

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Description

The gene MAP3K10 is very weakly expressed in human and bat datasets. The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. (provided by RefSeq, Jul 2008)

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome10 12 8 7 13 34 7 15 13
Read_Max
batR. aegyptiacusTranscriptome 27 33 14 23 23 37 17 27 24
Read_Max
bat_genomeR. aegyptiacusGenome 31 25 23 31 20 21 17 37 40
DESeq
humanH. sapiensGenome 194.82 217.21 186.66 100.24 177.41 597.11 83.46 189.65 229.34
DESeq
batR. aegyptiacusTranscriptome 121.98 148.95 109.72 131.94 135.7 115.2 89.99 142.28 124.33
DESeq
bat_genomeR. aegyptiacusGenome 385.01 447.22 474.21 403.88 387.3 395.54 378.97 408.37 503.44

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 194.82 100.24 83.46 -0.96 -1.22 -0.26
7h 217.21 177.41 189.65 -0.29 -0.2 0.1
23h 186.66 597.11 229.34 1.68 0.3 -1.38

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 194.82 217.21 186.66 0.16 -0.06 -0.22
Ebov 100.24 177.41 597.11 0.82 2.57 1.75
Marv 83.46 189.65 229.34 1.18 1.46 0.27

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 121.98 131.94 89.99 0.11 -0.44 -0.55
7h 148.95 135.7 142.28 -0.13 -0.07 0.07
23h 109.72 115.2 124.33 0.07 0.18 0.11

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 121.98 148.95 109.72 0.29 -0.15 -0.44
Ebov 131.94 135.7 115.2 0.04 -0.2 -0.24
Marv 89.99 142.28 124.33 0.66 0.47 -0.19