NFKBIE

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NFKBIE IKBE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon pdf

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Description

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. It is strongly upregulated after 23 hours of ebola virus infection and constantly expressed in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome21 16 20 20 21 180 24 25 39
Read_Max
batR. aegyptiacusTranscriptome 32 41 41 33 25 43 19 39 59
Read_Max
bat_genomeR. aegyptiacusGenome 34 31 28 34 21 28 17 49 55
DESeq
humanH. sapiensGenome 199.9 167.24 149.92 261.08 169.28 1599.85 238.72 212.83 338.08
DESeq
batR. aegyptiacusTranscriptome 194.23 186.17 302.72 250.06 209.07 347.46 163.41 237.3 344.76
DESeq
bat_genomeR. aegyptiacusGenome 256.1 314.88 363.74 265.63 271.22 483.0 230.53 289.43 446.08

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 199.9 261.08 238.72 0.39 0.26 -0.13
7h 167.24 169.28 212.83 0.02 0.35 0.33
23h 149.92 1599.85 338.08 3.42 1.17 -2.24

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 199.9 167.24 149.92 -0.26 -0.42 -0.16
Ebov 261.08 169.28 1599.85 -0.63 2.62 3.24
Marv 238.72 212.83 338.08 -0.17 0.5 0.67

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 194.23 250.06 163.41 0.36 -0.25 -0.61
7h 186.17 209.07 237.3 0.17 0.35 0.18
23h 302.72 347.46 344.76 0.2 0.19 -0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 194.23 186.17 302.72 -0.06 0.64 0.7
Ebov 250.06 209.07 347.46 -0.26 0.47 0.73
Marv 163.41 237.3 344.76 0.54 1.08 0.54