AKT3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
AKT3	MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2,PKBG	v-akt murine thymoma viral oncogene homolog 3	NM_181690	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The v-akt murine thymoma viral oncogene homolog 3 (EC:2.7.11.1) is involved in the MAPK, ErbB, Ras, Rap1, cGMP-PKG, cAMP, Chemokine, HIF-1, FoxO, mTOR, PI3K-Akt, VEGF, Toll-like receptor, T cell receptor, B cell receptor, TNF, Neurotrophin, Jak-STAT, Fc epsilon RI, Insulin, Estrogen, Prolactin, Thyroid hormone, Adipocytokine and AMPK signaling pathways. Also in Apoptosis, Adrenergic signaling in cardiomyocytes, Osteoclast differentiation, Focal adhesion, Tight junction, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Fc gamma R-mediated phagocytosis, Cholinergic and Dopaminergic synapses, Progesterone-mediated oocyte maturation, Non-alcoholic fatty liver disease (NAFLD), Carbohydrate digestion and absorption, Chagas disease (American trypanosomiasis), Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Influenza A, HTLV-I infection, Epstein-Barr virus infection and Pathways in cancer.

It does not present a particularly interesting differential expression pattern in the samples analyzed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	7	13	10	8	17	16	8	15	8
Read_Max	R. aegyptiacus	Transcriptome	58	53	49	48	39	58	58	44	69
Read_Max	R. aegyptiacus	Genome	186	149	113	152	108	121	159	177	260
DESeq	H. sapiens	Genome	144.08	187.64	134.04	123.05	152.21	160.23	120.3	129.7	135.83
DESeq	R. aegyptiacus	Transcriptome	409.31	363.17	325.93	296.76	309.82	461.66	501.58	301.74	407.74
DESeq	R. aegyptiacus	Genome	2395.98	1779.74	1864.46	2266.27	1959.93	2790.97	2739.36	1868.97	2253.5

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	144.08	123.05	120.3	-0.23	-0.26	-0.03
7h	187.64	152.21	129.7	-0.3	-0.53	-0.23
23h	134.04	160.23	135.83	0.26	0.02	-0.24

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	144.08	187.64	134.04	0.38	-0.1	-0.49
Ebov	123.05	152.21	160.23	0.31	0.38	0.07
Marv	120.3	129.7	135.83	0.11	0.18	0.07

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	409.31	296.76	501.58	-0.46	0.29	0.76
7h	363.17	309.82	301.74	-0.23	-0.27	-0.04
23h	325.93	461.66	407.74	0.5	0.32	-0.18

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	409.31	363.17	325.93	-0.17	-0.33	-0.16
Ebov	296.76	309.82	461.66	0.06	0.64	0.58
Marv	501.58	301.74	407.74	-0.73	-0.3	0.43

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material