SHC1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SHC1 SHC, SHCA,p66, ShcA SHC (Src homology 2 domain containing) transforming protein 1 NM_183001 pdf

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Description

Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 3, mRNA.This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome443 648 540 544 735 1087 649 829 562
Read_Max
batR. aegyptiacusTranscriptome 220 204 115 129 113 227 119 178 222
Read_Max
bat_genomeR. aegyptiacusGenome 199 142 110 159 85 115 130 150 187
DESeq
humanH. sapiensGenome 7783.4 8135.51 7081.83 8330.27 7457.38 13360.24 8414.27 8884.18 9345.66
DESeq
batR. aegyptiacusTranscriptome 1533.42 1468.73 1299.49 1111.71 1167.27 1746.13 1331.44 1192.39 1639.33
DESeq
bat_genomeR. aegyptiacusGenome 1031.27 847.88 864.73 1124.74 824.82 1185.31 1139.15 772.33 1006.88

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7783.4 8330.27 8414.27 0.1 0.11 0.01
7h 8135.51 7457.38 8884.18 -0.13 0.13 0.25
23h 7081.83 13360.24 9345.66 0.92 0.4 -0.52

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7783.4 8135.51 7081.83 0.06 -0.14 -0.2
Ebov 8330.27 7457.38 13360.24 -0.16 0.68 0.84
Marv 8414.27 8884.18 9345.66 0.08 0.15 0.07

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1533.42 1111.71 1331.44 -0.46 -0.2 0.26
7h 1468.73 1167.27 1192.39 -0.33 -0.3 0.03
23h 1299.49 1746.13 1639.33 0.43 0.34 -0.09

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1533.42 1468.73 1299.49 -0.06 -0.24 -0.18
Ebov 1111.71 1167.27 1746.13 0.07 0.65 0.58
Marv 1331.44 1192.39 1639.33 -0.16 0.3 0.46