ITGA3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ITGA3	CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a,CD49c	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	NM_005501	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) is involved in the PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Hematopoietic cell lineage, Regulation of actin cytoskeleton, Pathways in cancer, Small cell lung cancer, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy.

There was practically no expression in the human samples, but in the samples from bats, there was slight upregulation in Marburg virus infection and slight downregulation in ebola infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	4	2	3	2	5	2	4	6	3
Read_Max	R. aegyptiacus	Transcriptome	243	250	154	169	138	134	111	184	261
Read_Max	R. aegyptiacus	Genome	258	190	130	245	115	75	92	223	293
DESeq	H. sapiens	Genome	26.37	11.2	3.98	13.55	13.19	6.26	21.18	31.38	27.1
DESeq	R. aegyptiacus	Transcriptome	2833.11	3289.56	3302.81	2969.6	2690.54	2264.53	2149.06	2742.36	4188.23
DESeq	R. aegyptiacus	Genome	3678.19	3786.73	4282.35	4517.74	3530.33	3050.74	2894.55	3469.14	5447.09

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	26.37	13.55	21.18	-0.96	-0.32	0.64
7h	11.2	13.19	31.38	0.24	1.49	1.25
23h	3.98	6.26	27.1	0.65	2.77	2.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	26.37	11.2	3.98	-1.24	-2.73	-1.49
Ebov	13.55	13.19	6.26	-0.04	-1.11	-1.08
Marv	21.18	31.38	27.1	0.57	0.36	-0.21

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2833.11	2969.6	2149.06	0.07	-0.4	-0.47
7h	3289.56	2690.54	2742.36	-0.29	-0.26	0.03
23h	3302.81	2264.53	4188.23	-0.54	0.34	0.89

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2833.11	3289.56	3302.81	0.22	0.22	0.01
Ebov	2969.6	2690.54	2264.53	-0.14	-0.39	-0.25
Marv	2149.06	2742.36	4188.23	0.35	0.96	0.61

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material