RB1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| RB1 | RB1, OSRC, PPP1R130, RB, p105-Rb, pRb, pp110,RB | retinoblastoma 1 | NM_000321 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
RB1 shows differential expression in human (upregulation during ebola infection and 2 fold downregulation during marburg infection after 7h), but not in bat cell culter infected with EBOV or MARV. However, there is a probable alternative splicing event (exon skipping) in 23 hours pi in EOV infect human cell.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 516 | 473 | 461 | 457 | 552 | 694 | 641 | 653 | 328 |
Read_Max |  | R. aegyptiacus | Transcriptome | 65 | 60 | 55 | 74 | 47 | 83 | 50 | 79 | 64 |
Read_Max |  | R. aegyptiacus | Genome | 109 | 73 | 48 | 81 | 46 | 48 | 72 | 102 | 78 |
DESeq | | H. sapiens | Genome | 7044.64 | 6049.87 | 6476.2 | 6136.73 | 6407.86 | 8258.41 | 6234.42 | 5493.34 | 5557.34 |
DESeq | | R. aegyptiacus | Transcriptome | 645.39 | 627.31 | 617.88 | 820.52 | 735.81 | 769.63 | 663.99 | 766.07 | 677.15 |
DESeq | | R. aegyptiacus | Genome | 1258.15 | 1250.38 | 1132.51 | 1196.83 | 1247.84 | 1301.49 | 1353.94 | 1258.41 | 1203.81 |