RB1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
RB1 RB1, OSRC, PPP1R130, RB, p105-Rb, pRb, pp110,RB retinoblastoma 1 NM_000321 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

RB1 shows differential expression in human (upregulation during ebola infection and 2 fold downregulation during marburg infection after 7h), but not in bat cell culter infected with EBOV or MARV. However, there is a probable alternative splicing event (exon skipping) in 23 hours pi in EOV infect human cell.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome516 473 461 457 552 694 641 653 328
Read_Max
batR. aegyptiacusTranscriptome 65 60 55 74 47 83 50 79 64
Read_Max
bat_genomeR. aegyptiacusGenome 109 73 48 81 46 48 72 102 78
DESeq
humanH. sapiensGenome 7044.64 6049.87 6476.2 6136.73 6407.86 8258.41 6234.42 5493.34 5557.34
DESeq
batR. aegyptiacusTranscriptome 645.39 627.31 617.88 820.52 735.81 769.63 663.99 766.07 677.15
DESeq
bat_genomeR. aegyptiacusGenome 1258.15 1250.38 1132.51 1196.83 1247.84 1301.49 1353.94 1258.41 1203.81

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7044.64 6136.73 6234.42 -0.2 -0.18 0.02
7h 6049.87 6407.86 5493.34 0.08 -0.14 -0.22
23h 6476.2 8258.41 5557.34 0.35 -0.22 -0.57

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7044.64 6049.87 6476.2 -0.22 -0.12 0.1
Ebov 6136.73 6407.86 8258.41 0.06 0.43 0.37
Marv 6234.42 5493.34 5557.34 -0.18 -0.17 0.02

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 645.39 820.52 663.99 0.35 0.04 -0.31
7h 627.31 735.81 766.07 0.23 0.29 0.06
23h 617.88 769.63 677.15 0.32 0.13 -0.18

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 645.39 627.31 617.88 -0.04 -0.06 -0.02
Ebov 820.52 735.81 769.63 -0.16 -0.09 0.06
Marv 663.99 766.07 677.15 0.21 0.03 -0.18